COMPARING THE URINARY VALUE OF N-ACETYL-β-D-GLUCOSAMINIDASE (NAG) AND β2-MICROGLOBULINURIA (β2M) IN ACUTE KIDNEY DAMAGE IN CHILDREN

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MERRIKHI ALIREZA; MORADI REIHANE; TAHERI DIANA; BARADARAN AZAR

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Journal: Journal of Isfahan Medical School Year:2013 | Volume:31 | Issue:229 Page(s): 314-322

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Title

COMPARING THE URINARY VALUE OF N-ACETYL-β-D-GLUCOSAMINIDASE (NAG) AND β2-MICROGLOBULINURIA (β2M) IN ACUTE KIDNEY DAMAGE IN CHILDREN

Author(s)

MERRIKHI ALIREZA | MORADI REIHANE | TAHERI DIANA | BARADARAN AZAR | Issue Writer Certificate

Keywords

N-ACETYL-β-D-GLUCOSAMINIDASE (NAG)Q2

β2-MICROGLOBULINURIAQ2

ACUTE KIDNEY INJURYQ2

GLOMERULAR DISEASEQ2

Abstract

Background: At this study, we aimed to compare the urinary value of N-acetyl-b-D-glucosaminidase (NAG) with b2-microglobulinuria (b2M) to find the best marker for early diagnosis of acute kidney damage in children. These markers were used instead of routine evaluations of renal function tests such as creatinine (Cr).Methods: This study was conducted on 80 pediatric patients with the age range of 3 to 16 years old. They were categorized into patients with GLOMERULAR DISEASE, tubular disease, and finally patients who had urological problems. Urinary NAG, b2M and Cr were measured. The ratio of NAG/Cr and b2M/Cr was compared between the groups. For analysis, one way ANOVA, chi-square, post-hoc least significant difference (LSD) and receiver operating characteristic (ROC) curve were used.Findings: The mean of NAG/Cr in GLOMERULAR DISEASE group was significantly more than the other groups (P<0.05). There was no significant difference of NAG/Cr between two groups of tubular disease and urological disease patients’ group (P>0.05). The mean of NAG/Cr in two groups of patients with tubular and urological disease was more than control group (P>0.05). In patients with GLOMERULAR DISEASE group, the mean of b2M/Cr ration was more than other groups. Besides, the mean of b2M/Cr in two groups of patients with tubular and urological disease was more than control group (P>0.05). In all groups, the diagnostic value of NAG/Cr was more than b2M/Cr.Conclusion: Urinary measurement of NAG/Cr is a simple, cost benefit and non-invasive method which can be used to detect early stages of renal injury such as glomerular, tubular or urological problems.

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APA: Copy

MERRIKHI, ALIREZA, MORADI, REIHANE, TAHERI, DIANA, & BARADARAN, AZAR. (2013). COMPARING THE URINARY VALUE OF N-ACETYL-β-D-GLUCOSAMINIDASE (NAG) AND β2-MICROGLOBULINURIA (β2M) IN ACUTE KIDNEY DAMAGE IN CHILDREN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(229), 314-322. SID. https://sid.ir/paper/50708/en

Vancouver: Copy

MERRIKHI ALIREZA, MORADI REIHANE, TAHERI DIANA, BARADARAN AZAR. COMPARING THE URINARY VALUE OF N-ACETYL-β-D-GLUCOSAMINIDASE (NAG) AND β2-MICROGLOBULINURIA (β2M) IN ACUTE KIDNEY DAMAGE IN CHILDREN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2013;31(229):314-322. Available from: https://sid.ir/paper/50708/en

IEEE: Copy

ALIREZA MERRIKHI, REIHANE MORADI, DIANA TAHERI, and AZAR BARADARAN, “COMPARING THE URINARY VALUE OF N-ACETYL-β-D-GLUCOSAMINIDASE (NAG) AND β2-MICROGLOBULINURIA (β2M) IN ACUTE KIDNEY DAMAGE IN CHILDREN,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 229, pp. 314–322, 2013, [Online]. Available: https://sid.ir/paper/50708/en

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