THE ASSOCIATION BETWEEN CA POLYMORPHISM IN SRC GENE AND RISK OF BREAST CANCER

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HAFEZI GHAZALEH; tavssoli manoochehr; HEMMATI SIMIN; SAFARI FOROUZAN

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Journal: Journal of Isfahan Medical School Year:2017 | Volume:35 | Issue:419 Page(s): 87-92

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Title

THE ASSOCIATION BETWEEN CA POLYMORPHISM IN SRC GENE AND RISK OF BREAST CANCER

Author(s)

HAFEZI GHAZALEH | tavssoli manoochehr | HEMMATI SIMIN | SAFARI FOROUZAN | Issue Writer Certificate

Keywords

BREAST CANCERQ2

GENETIC POLYMORPHISMQ1

SRC GENEQ1

AMINO ACID REPEAT SEQUENCEQ1

Abstract

Background: BREAST CANCER is the most common malignancy in women and is the first cause of death among the women in the world. Disruption of gene expression of src family members has been observed in many cancers. Repeated sequences in introns influence gene expression, splicing or change the structure of product. In the present study, the association between CA polymorphism in intron 2 of the SRC GENE and the risk of BREAST CANCER was investigated.Methods: This was a cohort study on 119 patients with BREAST CANCER and 145 healthy people. Genomic DNAs were extracted from white blood cells. CA dinucleotide region of the SRC GENE was amplified via polymerase chain reaction (PCR) technique and the number of CA repeats was determined using polyacrylamide gel electrophoresis. Findings: Distribution of the CA repeats in SRC GENE in the target population was between 14-27 repeats. The most common allele in two groups was 21. The frequency of the allele 22 in patients was significantly higher than healthy group.26 genotypes were identified and the genotype 21.21 was the most common one among the two groups. The genotype 22.22 was more frequent in patients than in healthy group. Chi-square test and odds ratio (OR) showed that women with allele 22 were exposed more to BREAST CANCER. Women with genotype 22.22 had a higher risk of developing BREAST CANCER.Conclusion: it can be concluded that the allele 22 can have a role in developing BREAST CANCER.

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References

CYR61 AS MEDIATOR OF SRC SIGNALING IN TRIPLE NEGATIVE BREAST CANCER CELLS

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APA: Copy

HAFEZI, GHAZALEH, tavssoli, manoochehr, HEMMATI, SIMIN, & SAFARI, FOROUZAN. (2017). THE ASSOCIATION BETWEEN CA POLYMORPHISM IN SRC GENE AND RISK OF BREAST CANCER. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 35(419), 87-92. SID. https://sid.ir/paper/50837/en

Vancouver: Copy

HAFEZI GHAZALEH, tavssoli manoochehr, HEMMATI SIMIN, SAFARI FOROUZAN. THE ASSOCIATION BETWEEN CA POLYMORPHISM IN SRC GENE AND RISK OF BREAST CANCER. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2017;35(419):87-92. Available from: https://sid.ir/paper/50837/en

IEEE: Copy

GHAZALEH HAFEZI, manoochehr tavssoli, SIMIN HEMMATI, and FOROUZAN SAFARI, “THE ASSOCIATION BETWEEN CA POLYMORPHISM IN SRC GENE AND RISK OF BREAST CANCER,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 35, no. 419, pp. 87–92, 2017, [Online]. Available: https://sid.ir/paper/50837/en

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