THE IRON OXIDE NANORODS TOXICITY ON L929 CELL LINE

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GHASEMPOUR SARIEH; SHOKRGOZAR MOHAMMAD ALI; GHASEMPOUR ROGHAYEH; ALIPOUR MOHSEN

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Information Journal Paper

Title

THE IRON OXIDE NANORODS TOXICITY ON L929 CELL LINE

Author(s)

GHASEMPOUR SARIEH | SHOKRGOZAR MOHAMMAD ALI | GHASEMPOUR ROGHAYEH | ALIPOUR MOHSEN | Issue Writer Certificate

Keywords

IRON OXIDE NANORODSQ2

MTTQ1

VIABILITYQ3

UREA COATED IRON OXIDEQ2

L929 CELL LINEQ2

Abstract

Background: Major applications of nanotechnology in industry, agriculture, biology and medicine are growing. Given the broad range of nanoscience in medical sciences, evaluation of the cytotoxicity of IRON OXIDE NANORODS through comparing VIABILITY and apoptosis formed the objectives of this study.Methods: In this study, the nanorods were synthesized by coprecipitation method and transmission electron microscopy and scanning electron microscopy was used for determination of the size and shape of nanoparticles. 200 and 800mg/ml urea and polyethylene glycol (PEG) coated nanorods, in forms of modified and non-modified, were assessed for toxicity using MTT assay 48 and 72 hours later.Findings: The length and diameter of the urea- and PEG-coated nanorods were 150 and 15 nm and 150 and 23 nm, respectively. VIABILITY of cells exposed to non-modified IRON OXIDE NANORODS was less than modified form. This toxicity showed uptrend with increasing dose. VIABILITY of the cells exposed to PEG-coated IRON OXIDE NANORODS was lower than urea-coated once.Conclusion: It appears that the increase in apoptosis affected by non-modified IRON OXIDE NANORODS might be resulted from formation of protein rings called Hard Corona around the nanorods. In addition, more increase of cell death by PEG-coated nanorods compared to urea-coated nanorods is indicator of the effect of type of coverage and type of cells on their cytotoxicity.

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APA: Copy

GHASEMPOUR, SARIEH, SHOKRGOZAR, MOHAMMAD ALI, GHASEMPOUR, ROGHAYEH, & ALIPOUR, MOHSEN. (2014). THE IRON OXIDE NANORODS TOXICITY ON L929 CELL LINE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(263), 1973-1984. SID. https://sid.ir/paper/50873/en

Vancouver: Copy

GHASEMPOUR SARIEH, SHOKRGOZAR MOHAMMAD ALI, GHASEMPOUR ROGHAYEH, ALIPOUR MOHSEN. THE IRON OXIDE NANORODS TOXICITY ON L929 CELL LINE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2014;31(263):1973-1984. Available from: https://sid.ir/paper/50873/en

IEEE: Copy

SARIEH GHASEMPOUR, MOHAMMAD ALI SHOKRGOZAR, ROGHAYEH GHASEMPOUR, and MOHSEN ALIPOUR, “THE IRON OXIDE NANORODS TOXICITY ON L929 CELL LINE,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 263, pp. 1973–1984, 2014, [Online]. Available: https://sid.ir/paper/50873/en

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