THE-EFFECT OF DELAYING GASTRIC EMPTYING VIA PHYSIOLOGICAL INTERVENTION WITH 10% SUCROSE ON HELICOBACTER PYLORI ERADICATION

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EMAMI M.H.; SHIR MOHAMMADI A.; DAGHAGHZADEH H.; FARAJZADEGAN Z.

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Journal: Journal of Isfahan Medical School Year:2005 | Volume:23 | Issue:79 Page(s): 50-55

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Title

THE-EFFECT OF DELAYING GASTRIC EMPTYING VIA PHYSIOLOGICAL INTERVENTION WITH 10% SUCROSE ON HELICOBACTER PYLORI ERADICATION

Author(s)

EMAMI M.H. | SHIR MOHAMMADI A. | DAGHAGHZADEH H. | FARAJZADEGAN Z. | Issue Writer Certificate

Keywords

HELICOBACTER PYLORIQ3

ERADICATIONQ2

ASPARTAMQ2

Abstract

Introduction: Helicobacter (H. pylori) infection is the most common chronic bacterial infection at any age. It is a worldwide problem and the second commonest cause of gastric 'cancer. Humans are the main reservoir of this infection. ERADICATION of H. pylori infection is essential to effective treatment of peptic ulcer disease (PUD). ERADICATION prevents the return and complications of ulcers and also can reduce future morbidity and mortality from PUD and gastric carcinoma. H. pylori is naturally resistant to several commonly used antibiotics. We aimed to compare the efficacy of gastric emptying delay in quadruple drug regimen versus standard quadruple therapy for one week in H. pylori ERADICATION.Methods: 140 patients with endoscopically confirmed H. pylori infection, were randomly assigned to groups A and B. Group B received omeprazole (20 mg bid), furazolidone (200 mg bid), amoxicillin (1 g bid), bismuth (240 mg bid) plus ASPARTAM as placebo (4 tablets in 500 cc of water twice daily with drugs). Group A was treated with the same regimen plus 10% sucrose syrup: 125 cc administered 5 minutes before taking medications and 375 cc with medications. Endoscopic findings, as well as data on the presence of gastrointestinal or non-gastrointestinal symptoms were recorded in questionnaires. Side effects were documented by diary chart and interviews during treatment. All of the patients received the medications only for one week; then they were treated with omeprazole for 4 weeks. H. pylori ERADICATION was assessed at least 2 weeks after the end of therapy using C14 Urea Breath Test. ERADICATION was confirmed if UBT was negative.Result: 140 patients (66 males and 74 females, mean age: 41.97 years in group A and 39.34 years in group B) were studied. 130 subjects completed the study. Four patients in group A and one patient in group B did not tolerate the regimen and were excluded from the study. Excellent tolerance was observed in 92.85% of patients in group A and 94.3% of those in group B. Severe side effects were observed in 5.71% of patients group A (severe nausea, anorexia) and 1.4% of patients in group B (headache, malaise). The ERADICATION rate assessed by per-protocol analysis was higher in group A than in group B (92.07% [n=63] versus 85.08% [n=67], respectively, P=0.034).Discussion: Quadruple regimen containing high dose of furazolidone only for one week is effective and recommended; the use of sucrose syrup can increase the ERADICATION rate. Excellent drug tolerance (>80%) was seen in 92.8% of patients in group A; hence it seems that the observed complications cannot limit the treatment and we recommend this therapeutic regimen for all H.pylori-positive patients who are candidates for ERADICATION therapy.

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APA: Copy

EMAMI, M.H., SHIR MOHAMMADI, A., DAGHAGHZADEH, H., & FARAJZADEGAN, Z.. (2005). THE-EFFECT OF DELAYING GASTRIC EMPTYING VIA PHYSIOLOGICAL INTERVENTION WITH 10% SUCROSE ON HELICOBACTER PYLORI ERADICATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 23(79), 50-55. SID. https://sid.ir/paper/50912/en

Vancouver: Copy

EMAMI M.H., SHIR MOHAMMADI A., DAGHAGHZADEH H., FARAJZADEGAN Z.. THE-EFFECT OF DELAYING GASTRIC EMPTYING VIA PHYSIOLOGICAL INTERVENTION WITH 10% SUCROSE ON HELICOBACTER PYLORI ERADICATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2005;23(79):50-55. Available from: https://sid.ir/paper/50912/en

IEEE: Copy

M.H. EMAMI, A. SHIR MOHAMMADI, H. DAGHAGHZADEH, and Z. FARAJZADEGAN, “THE-EFFECT OF DELAYING GASTRIC EMPTYING VIA PHYSIOLOGICAL INTERVENTION WITH 10% SUCROSE ON HELICOBACTER PYLORI ERADICATION,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 23, no. 79, pp. 50–55, 2005, [Online]. Available: https://sid.ir/paper/50912/en

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