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Information Journal Paper

Title

QT PROLONGATION AND CARDIAC AUTONOMIC NEUROPATHY IN DIABETIC PATIENTS

Pages

  51-56

Keywords

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Abstract

 Cardiovascular complications are the most common cause of mortality and morbidity in noninsulin dependent diabetes mellitus (NIDDM).Autonomic neuropathy is one of the complications of NIDDM which may also involve cardiovascular system. Autonomic system abnormality may increase QTc interval On the other hand patients with prolonged QTc interval are prone to ventricular arrhythmia, especially unique torsade-de-point and also sudden cardiac death. This study is aimed to detect the prevalence of QT c prolongation in diabetic and nondiabetic patients as well as its correlation with diabetic autonomic neuropathy.This study includes 200 diabetic (case group) and 200 nondiabetic patients (control group) with comparable age and gender. Evaluation of autonomic nervous system was carried out in all cases with prolonged QT c interval Autonomic nervous system evaluation in control group also was performed. The results of study in the case and the control groups were compared.The prevalance of prolonged QT c interval was significantly higher in the case group in comparison with the control group, 8 percent versus 2 percent respectively.(P value = 0.012, OR=4.3).Sympathetic nervous system evaluation test in cases with QTc Interval prolongation and negative exercise test demonstrates abnormal results in more than 50% of case group (OR=3).Parasympathetic nervous system evaluation test in cases with QTc interval prolongation showed abnormal results in comparison with control group (OR=9).Abnormality of parasympathetic nervous system is more common than (3 fold) abnormality in sympathetic nervous system.With regard to the prolonged QT c interval in the case group in comparison with the control group and abnormal autonomic nervous system function in more than half of the case group, the probability of ventricular arrhythmia, torsade de points, has incresed. The mentioned ones are in increased risk of sudden cardiac death. Rendering approaches for decreasing the risk of sudden cariac death in diabetic patients are seriously recommended.

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