THE EFFECT OF SHORT-TERM PHYSICAL ACTIVITY ON WITHDRAWAL SYMPTOMS WITH OR WITHOUT MPFC AREA IN MALE RATS INFLUENCED BY MORPHINE

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SAEDI MARGHMALEKI VAJIHEH; ALAEI HOJJATALLAH; AZIZI MALEKABADI HAMID

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Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2013 | Volume:31 | Issue:243 Page(s): 997-1006

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Title

THE EFFECT OF SHORT-TERM PHYSICAL ACTIVITY ON WITHDRAWAL SYMPTOMS WITH OR WITHOUT MPFC AREA IN MALE RATS INFLUENCED BY MORPHINE

Author(s)

SAEDI MARGHMALEKI VAJIHEH | ALAEI HOJJATALLAH | AZIZI MALEKABADI HAMID | Issue Writer Certificate

Keywords

EXERCISEQ2

WITHDRAWAL SYMPTOMQ2

MPFCQ2

MORPHINEQ2

Abstract

Background: Drug addiction is one of the social damages that researchers have tried to find suitable strategies for prevention and treatment of it. Meanwhile, short-term physical activity is acceptable parameter for treatment and prevention of addiction. On the other hand, prefrontal cortex, for a long time as mediating, is involved in many of the complex behavioral responses, especially those associated with addiction and drug abuse. In this paper, the effects of short-term physical activity (treadmill running) on WITHDRAWAL SYMPTOM with or without MPFC area have been evaluated.Methods: This experimental study was done on Wistar rats weighing 250 ± 300 g separated to four groups: control, shame, test 1 and test 2; one of the test groups had surgery and lesion on MPFC area. For studying the effects of short-term physical activity, we used treadmill with adjustable speed of 17 m/minute and a 15-degrees slope; after the injection of three doses of MORPHINE, 10, 20, 40 mg in 9 days and running on the treadmill, in the tenth day, the symptoms of addiction were evaluated.Findings: The MORPHINE injection and running on the treadmill without MPFC region destruction tended to decreasing MORPHINE tendency. There was a significant difference between the rats, with or without MPFC area, received MORPHINE but did not run on the treadmill in MORPHINE tendency (P<0.05).Conclusion: It seems that short-term physical activity (treadmill running) decreases the tendency of using MORPHINE with MPFC area in comparison with other groups, especially with group operated in their MPFC area.

Cites

THE EFFECT OF AEROBIC EXERCISE ON TENDENCY TO CONSUMPTION OF MORPHINE IN MALE RAT

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APA: Copy

SAEDI MARGHMALEKI, VAJIHEH, ALAEI, HOJJATALLAH, & AZIZI MALEKABADI, HAMID. (2013). THE EFFECT OF SHORT-TERM PHYSICAL ACTIVITY ON WITHDRAWAL SYMPTOMS WITH OR WITHOUT MPFC AREA IN MALE RATS INFLUENCED BY MORPHINE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(243), 997-1006. SID. https://sid.ir/paper/50954/en

Vancouver: Copy

SAEDI MARGHMALEKI VAJIHEH, ALAEI HOJJATALLAH, AZIZI MALEKABADI HAMID. THE EFFECT OF SHORT-TERM PHYSICAL ACTIVITY ON WITHDRAWAL SYMPTOMS WITH OR WITHOUT MPFC AREA IN MALE RATS INFLUENCED BY MORPHINE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2013;31(243):997-1006. Available from: https://sid.ir/paper/50954/en

IEEE: Copy

VAJIHEH SAEDI MARGHMALEKI, HOJJATALLAH ALAEI, and HAMID AZIZI MALEKABADI, “THE EFFECT OF SHORT-TERM PHYSICAL ACTIVITY ON WITHDRAWAL SYMPTOMS WITH OR WITHOUT MPFC AREA IN MALE RATS INFLUENCED BY MORPHINE,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 243, pp. 997–1006, 2013, [Online]. Available: https://sid.ir/paper/50954/en

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