APOLIPOPROTEIN A, FACTOR VII AND TRIGLYCERIDE IN MI PATIENTS AND THEIR RELATION RESPONSE TO STREPTOKINASE

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NADERI GH.; ASGARI SEDIGHEH; HASHEMI M.; SABET B.; SABERI S.; KHAN-AHMAD M.

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2004 | Volume:22 | Issue:73 Page(s): 19-22

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Title

APOLIPOPROTEIN A, FACTOR VII AND TRIGLYCERIDE IN MI PATIENTS AND THEIR RELATION RESPONSE TO STREPTOKINASE

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Abstract

Introduction. Various studies indicate that elevated level of lipoprotein (a),triglyceride(TG)and F-VII are not only the riskfactor of myocardial infarction but also are effective in response to treatment, one of the treatment ways of MI is the use of thrombolytic drugs such as streptokinase (SK). There are different cross reaction factors that decrease the responsiveness to thrombolytic therapy. Streptokinase antibody and tissue-plasminogen activator inhibitor (P AI) are some these factors. Lp (a) is considered as a cross reaction factor because of its structural similarity to plasminogen, so it reduces the rate of response and the necrotic potency. Because of high prevalence of non-responsive to streptokinase in our population, it is very important to find factors cause it. In this study the serum level of Lp (a), F-VII and triglyceride in patients with MI who receive SK and its relation with positive response to treatment have been assessed.Methods. This cross-sectional study was done on 30 patients referred to Emergency Department that their clinical signs and ECG showed MI. Blood sampling and ECG were done for these patients, then 1.5 and 3 hours after getting SK, ECG was repeated and compared with the first one. The serum level of Lp (a), TG and F-VII of patients with positive response to SK and those with negative response to SK was measured. The results were statistically assessed by t-student, Man-Whitney tests and by correlation coefficient.Results. There wasn't any significant difference due to three factors in the group with positive response to SK and the group with negative response to SK. The mean Lp (a) in group with negative response to SK was less than the other group. The correlation of response to SK due to TG and F-VII was less than Lp (a).Discussion. The elevated level of Lp (a), TG and F-VII is related with the occurrence of MI. The more higher the serum level of Lp (a), the positive response to SK is reduced, because of interaction effect of Lp (a). Comparing the serum level of F-VII and TG with Lp (a) showed that measurement of LP (a) is more important regarding positive response to treatment. Comparing the mean Lp (a) in the community and in patients with MI showed that in patients with MI, Lp (a) level is more higher than normal level. So paying more attention should be done to it as a risk factor.

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APA: Copy

NADERI, GH., ASGARI, SEDIGHEH, HASHEMI, M., SABET, B., SABERI, S., & KHAN-AHMAD, M.. (2004). APOLIPOPROTEIN A, FACTOR VII AND TRIGLYCERIDE IN MI PATIENTS AND THEIR RELATION RESPONSE TO STREPTOKINASE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 22(73), 19-22. SID. https://sid.ir/paper/50980/en

Vancouver: Copy

NADERI GH., ASGARI SEDIGHEH, HASHEMI M., SABET B., SABERI S., KHAN-AHMAD M.. APOLIPOPROTEIN A, FACTOR VII AND TRIGLYCERIDE IN MI PATIENTS AND THEIR RELATION RESPONSE TO STREPTOKINASE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2004;22(73):19-22. Available from: https://sid.ir/paper/50980/en

IEEE: Copy

GH. NADERI, SEDIGHEH ASGARI, M. HASHEMI, B. SABET, S. SABERI, and M. KHAN-AHMAD, “APOLIPOPROTEIN A, FACTOR VII AND TRIGLYCERIDE IN MI PATIENTS AND THEIR RELATION RESPONSE TO STREPTOKINASE,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 22, no. 73, pp. 19–22, 2004, [Online]. Available: https://sid.ir/paper/50980/en

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