THE EFFECT OF ORAL L-CARNITINE ON SERUM ALBUMIN AND INFLAMMATORY MARKERS LEVELS IN PATIENTS UNDER PERITONEAL DIALYSIS: A RANDOMIZED CONTROLLED TRIAL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MORTAZAVI MOJGAN; ASGARI SAHEL; GHASSAMI MARYAM; SEIRAFIAN SHIVA; TAHERI SHAHRAM; EMAMI NAINI AFSOON; ESHAGHIAN AFROOZ; GHOLAMREZAI ALI; FAYAZ LEILA; KARIMI SHIRIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2011 | Volume:29 | Issue:138 Page(s): 546-554

Download Full-Text

Persian Verion

View:

1,707

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF ORAL L-CARNITINE ON SERUM ALBUMIN AND INFLAMMATORY MARKERS LEVELS IN PATIENTS UNDER PERITONEAL DIALYSIS: A RANDOMIZED CONTROLLED TRIAL

Author(s)

Keywords

L-CARNITINEQ2

ALBUMINQ2

SYSTEMIC INFLAMMATIONQ2

MALNUTRITIONQ3

PERITONEAL DIALYSISQ2

Abstract

Background: MALNUTRITION is one of the most common complications among patients under maintenance dialysis which is related to systemic inflammatory processes. Decrease in serum ALBUMIN level, following MALNUTRITION, is an independent risk factor for cardio-vascular diseases in patients under dialysis.We aimed to evaluate the effect of oral L-CARNITINE supplementation on serum ALBUMIN and inflammatory factors (C reactive protein (CRP) and hemosysteine) in patients under PERITONEAL DIALYSIS.Methods: This randomized, double-blind, placebo-controlled trial was conducted on 48 patients under PERITONEAL DIALYSIS referring to Isfahan PERITONEAL DIALYSIS Center from 2009-2010. Patients were randomized to carnitine and placebo groups and received oral carnitine (250 mg, 3 tablets/day) or placebo for 9 months. Serum ALBUMIN level was checked every 3 months and serum CRP and hemosysteine levels were checked before and after the study and compared between the two groups.Findings: Compared to placebo group, serum ALBUMIN level was increased significantly from 3.30±0.51 to 3.70±0.53 mg/dl (P=0.044). In carnitine group, serum CRP level was increased from 2.35±2.49 to 3.37±4.80 mg/l (P=0.304) while in the placebo group it was significantly increased from 1.37±1.28 to 2.44±2.68 mg/l (P=0.039). In contrast, serum hemosysteine level was significantly increased in the carnitine group from 21.40±8.08 to 25.70±6.85 mgr/l (P=0.019) while its increase in the placebo groop was not significant (P=0.159). One patient in the carnitine group with history of hypertension experienced an increase in blood pressure that was controlled with a greater dose of antihypertensive drugs.Conclusion: In patients under PERITONEAL DIALYSIS, oral L-CARNITINE can increase serum ALBUMIN level and prevent CRP rising, but has no beneficial effect on hemosysteine. According to several reports on beneficial effects of L-CARNITINE on anemia and lipid profile in patients under dialysis, its supplementation is recommended for these patients.

Cites

No record.

References

No record.

Cite

APA: Copy

MORTAZAVI, MOJGAN, ASGARI, SAHEL, GHASSAMI, MARYAM, SEIRAFIAN, SHIVA, TAHERI, SHAHRAM, EMAMI NAINI, AFSOON, ESHAGHIAN, AFROOZ, GHOLAMREZAI, ALI, FAYAZ, LEILA, & KARIMI, SHIRIN. (2011). THE EFFECT OF ORAL L-CARNITINE ON SERUM ALBUMIN AND INFLAMMATORY MARKERS LEVELS IN PATIENTS UNDER PERITONEAL DIALYSIS: A RANDOMIZED CONTROLLED TRIAL. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 29(138), 546-554. SID. https://sid.ir/paper/51001/en

Vancouver: Copy

MORTAZAVI MOJGAN, ASGARI SAHEL, GHASSAMI MARYAM, SEIRAFIAN SHIVA, TAHERI SHAHRAM, EMAMI NAINI AFSOON, ESHAGHIAN AFROOZ, GHOLAMREZAI ALI, FAYAZ LEILA, KARIMI SHIRIN. THE EFFECT OF ORAL L-CARNITINE ON SERUM ALBUMIN AND INFLAMMATORY MARKERS LEVELS IN PATIENTS UNDER PERITONEAL DIALYSIS: A RANDOMIZED CONTROLLED TRIAL. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2011;29(138):546-554. Available from: https://sid.ir/paper/51001/en

IEEE: Copy

MOJGAN MORTAZAVI, SAHEL ASGARI, MARYAM GHASSAMI, SHIVA SEIRAFIAN, SHAHRAM TAHERI, AFSOON EMAMI NAINI, AFROOZ ESHAGHIAN, ALI GHOLAMREZAI, LEILA FAYAZ, and SHIRIN KARIMI, “THE EFFECT OF ORAL L-CARNITINE ON SERUM ALBUMIN AND INFLAMMATORY MARKERS LEVELS IN PATIENTS UNDER PERITONEAL DIALYSIS: A RANDOMIZED CONTROLLED TRIAL,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 29, no. 138, pp. 546–554, 2011, [Online]. Available: https://sid.ir/paper/51001/en

Related Journal Papers