EVALUATION OF LYMPHOCYTE ACTIVATION GENE3 (LAG-3) ON REGULATORY T CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS BY INTERVENTION EFFECT OF FINGOLIMOD

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Sedaghat Nahid; ZARKESH ESFAHANI SAYYED HAMID; ALSAHEBFOSOUL FERESHTEH; ETEMADIFAR MASOUD; OSTADI VAJIHEH; KIANPOUR FARIBORZ; AKBARI MOJTABA

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2016 | Volume:34 | Issue:387 Page(s): 701-706

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Title

EVALUATION OF LYMPHOCYTE ACTIVATION GENE3 (LAG-3) ON REGULATORY T CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS BY INTERVENTION EFFECT OF FINGOLIMOD

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Keywords

MULTIPLE SCLEROSISQ2

REGULATORY T CELLQ1

LYMPHOCYTE ACTIVATION GENE 3 (LAG-3)Q1

FINGOLIMODQ1

IMMUNE TOLERANCEQ1

Abstract

Background: Regulatory CD4+Foxp3+T cells (Tregs) play an important role in the prevention of autoimmune disease. It is also suggested that in MULTIPLE SCLEROSIS (MS), a central nervous system disease, an aberrant Treg function may play a role. Lymphocyte activation gene3 (LAG-3) as a surface marker of Treg cells with negative regulation of the immune system can effectively encounter with effector lymphocytes. In this study, we evaluated frequency of CD4+Foxp3+LAG-3+T cells before and after treatment with FINGOLIMOD.Methods: Blood samples was obtained from 20 patients with MULTIPLE SCLEROSIS before and after 1 months of FINGOLIMOD treatment, and from 12 age-matched healthy control subjects. Then pripheral blood mononuclear cell (PBMCs) were isolated and the frequency of Treg cells expressing LAG-3 were determined by flowcytometry.Findings: The frequency of CD4+Foxp3+LAG3+T cells in the peripheral blood of MS patients was increased when compared to baseline (P=0.005).Conclusion: Our findings suggested that FINGOLIMOD not only increases CD4+Foxp3+Treg cells, but also is able to enhance expression of LAG-3 on their surface. This is a new finding for the FINGOLIMOD on the immune system.

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APA: Copy

Sedaghat, Nahid, ZARKESH ESFAHANI, SAYYED HAMID, ALSAHEBFOSOUL, FERESHTEH, ETEMADIFAR, MASOUD, OSTADI, VAJIHEH, KIANPOUR, FARIBORZ, & AKBARI, MOJTABA. (2016). EVALUATION OF LYMPHOCYTE ACTIVATION GENE3 (LAG-3) ON REGULATORY T CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS BY INTERVENTION EFFECT OF FINGOLIMOD. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 34(387), 701-706. SID. https://sid.ir/paper/51020/en

Vancouver: Copy

Sedaghat Nahid, ZARKESH ESFAHANI SAYYED HAMID, ALSAHEBFOSOUL FERESHTEH, ETEMADIFAR MASOUD, OSTADI VAJIHEH, KIANPOUR FARIBORZ, AKBARI MOJTABA. EVALUATION OF LYMPHOCYTE ACTIVATION GENE3 (LAG-3) ON REGULATORY T CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS BY INTERVENTION EFFECT OF FINGOLIMOD. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2016;34(387):701-706. Available from: https://sid.ir/paper/51020/en

IEEE: Copy

Nahid Sedaghat, SAYYED HAMID ZARKESH ESFAHANI, FERESHTEH ALSAHEBFOSOUL, MASOUD ETEMADIFAR, VAJIHEH OSTADI, FARIBORZ KIANPOUR, and MOJTABA AKBARI, “EVALUATION OF LYMPHOCYTE ACTIVATION GENE3 (LAG-3) ON REGULATORY T CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS BY INTERVENTION EFFECT OF FINGOLIMOD,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 34, no. 387, pp. 701–706, 2016, [Online]. Available: https://sid.ir/paper/51020/en

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