EVALUATION OF HEPATIC INJURY FOLLOWING TRANSIENT LIGATION OF HEPATODUODENAL LIGAMENT (PRLNGLE MANEUVER) AT DIFFERENT TIMES IN RABBIT

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SABAHI A.R.; BEHDAD A.; KOLAHDOUZ M.

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2005 | Volume:23 | Issue:76 Page(s): 25-29

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Title

EVALUATION OF HEPATIC INJURY FOLLOWING TRANSIENT LIGATION OF HEPATODUODENAL LIGAMENT (PRLNGLE MANEUVER) AT DIFFERENT TIMES IN RABBIT

Author(s)

SABAHI A.R. | BEHDAD A. | KOLAHDOUZ M. | Issue Writer Certificate

Keywords

HEPATODUODENAL LIGAMENTQ4

HEPATIC ENZYMESQ3

ISCHEMIAQ2

PRINGLE MANEUVERQ4

Abstract

Introduction: The harmful effect of PRINGLE MANEUVER on hepatocytes is time-related and the most useful method of evaluating these effects is the liver function test. In this study, changes in the liver function test results following transient ligation of HEPATODUODENAL LIGAMENT of rabbit were evaluated.Materials and methods: In this experimental study, 20 rabbits were studied in four equal groups. In each animal, HEPATODUODENAL LIGAMENT was ligated for 30 minutes (group A), 45 minutes (group B), 60 minutes (group C) and 75 minutes (group D). Under general anesthesia liver biopsy was taken after performing the maneuver and levels of serum SGOT and SCPT were measured on the first, third, fifth and seventh post-operative days.Results: SGOT on the first post operative day was 806±494.6 U/L in group A, 656.5±337.6 U/L in group B, 1559.6±270.6 U/L in group C, and 1637.5±880.34 U/L in group D. The rise in SGOT was significant compared to preoperative levels (P<0.05).SGOT on the third post-operative day was 202.75±80.9 U/L in group A, 195.7±74.8 U/L in group B, 223.3±77.3 U/L in group C and 238.5±30.4 U/L in group C. This decrease in SGOT level is significant compared to the first post-operative day (P<0.05). The SGPT on the first post-operative day was 756.2±522.5 U/L in group A, 834.5±262.02 U/L in group B, 1200±239.5 U/L in group C and 2288±143.6 U/L in group D. The rise in SGPT was significant compared to preoperative levels (P<0.05). The SGPT on the 3rd post-operative day was 280±221 U/L in group A, 270±77.5 U/L in group B, 289.3±164.4 U/L in group C, and 489±122.5 U/L in group D. The decrease in SGPT level was significant compared to the first post-operative day (P<0.05).Discussion: Closure of HEPATODUODENAL LIGAMENT for 45 minutes is safe and closure of HEPATODUODENAL LIGAMENT for more than one hour leads to severe increase in HEPATIC ENZYMES and high mortality.

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APA: Copy

SABAHI, A.R., BEHDAD, A., & KOLAHDOUZ, M.. (2005). EVALUATION OF HEPATIC INJURY FOLLOWING TRANSIENT LIGATION OF HEPATODUODENAL LIGAMENT (PRLNGLE MANEUVER) AT DIFFERENT TIMES IN RABBIT. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 23(76), 25-29. SID. https://sid.ir/paper/51105/en

Vancouver: Copy

SABAHI A.R., BEHDAD A., KOLAHDOUZ M.. EVALUATION OF HEPATIC INJURY FOLLOWING TRANSIENT LIGATION OF HEPATODUODENAL LIGAMENT (PRLNGLE MANEUVER) AT DIFFERENT TIMES IN RABBIT. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2005;23(76):25-29. Available from: https://sid.ir/paper/51105/en

IEEE: Copy

A.R. SABAHI, A. BEHDAD, and M. KOLAHDOUZ, “EVALUATION OF HEPATIC INJURY FOLLOWING TRANSIENT LIGATION OF HEPATODUODENAL LIGAMENT (PRLNGLE MANEUVER) AT DIFFERENT TIMES IN RABBIT,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 23, no. 76, pp. 25–29, 2005, [Online]. Available: https://sid.ir/paper/51105/en

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