LOCAL BRAIN ISCHEMIA INDUCING IN RAT BY EMBOLIC MODEL OF STROKE

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TAVAKOLI MOHAMMAD ELAH; MOULOUDI R.A.; HESHMATIAN B.; RAHMANI MOHAMMAD REZA; REZVANI M.E.

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2008 | Volume:26 | Issue:89 Page(s): 162-170

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Title

LOCAL BRAIN ISCHEMIA INDUCING IN RAT BY EMBOLIC MODEL OF STROKE

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Keywords

BRAIN ISCHEMIAQ2

EMBOLIC MODELQ3

BRAIN EDEMAQ2

NEUROLOGICAL DEFICITSQ3

Abstract

Background: In patients affected with stroke, most ischemic episodes (80-90%) occur due to occlusion of middle cerebral artery (MCA).Methods: Some of blood through femoral artery was withdrawn into a PE- 50 catheter and kept for 2 h in room temperature and 22 h at 4oC to allow old clot formation. Then the catheter was advanced 17 mm in the internal carotid artery until its tip was 1 to 2 mm away from MCA origin. 3-5ml the preformed clot or 5ml saline (for sham- operated animals) were injected. Behavioral deficits and seizure activities were recorded at 2, 24, and 48 hours after clot injection. Then the rats were decapitated to remove the brains and prepare them for Tetrazoliume chloride (TTC) staining and analyzing.Findings: When 3 or 5 Yl clots were injected, infarct volume was 29.35±1.26% and 16.15±94% respectively (p<0.05). BRAIN EDEMA also was 8.6±1.65% and 3±1.74%, respectively (p<0.05). There was a significant correlation between infarct volume and BRAIN EDEMA (r=0.56, p<0.05). Behavioral deficit score at 48 hours after clot injection between two groups were significantly different (p<0.05).Conclusion: This model is very similar to thromboembolic stroke in human and prepares a reliable method for investigating the stroke mechanism. It would also be useful for studying thromboembolic agents effect on stroke and brain ischemic injury.

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APA: Copy

TAVAKOLI, MOHAMMAD ELAH, MOULOUDI, R.A., HESHMATIAN, B., RAHMANI, MOHAMMAD REZA, & REZVANI, M.E.. (2008). LOCAL BRAIN ISCHEMIA INDUCING IN RAT BY EMBOLIC MODEL OF STROKE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 26(89), 162-170. SID. https://sid.ir/paper/51111/en

Vancouver: Copy

TAVAKOLI MOHAMMAD ELAH, MOULOUDI R.A., HESHMATIAN B., RAHMANI MOHAMMAD REZA, REZVANI M.E.. LOCAL BRAIN ISCHEMIA INDUCING IN RAT BY EMBOLIC MODEL OF STROKE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2008;26(89):162-170. Available from: https://sid.ir/paper/51111/en

IEEE: Copy

MOHAMMAD ELAH TAVAKOLI, R.A. MOULOUDI, B. HESHMATIAN, MOHAMMAD REZA RAHMANI, and M.E. REZVANI, “LOCAL BRAIN ISCHEMIA INDUCING IN RAT BY EMBOLIC MODEL OF STROKE,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 26, no. 89, pp. 162–170, 2008, [Online]. Available: https://sid.ir/paper/51111/en

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