PREVENTIVE IMPACTS OF SELENIUM ENRICHED YEAST ON LIVER AND ENZYME ACTIVITY AFTER COLORECTAL CANCER INDUCED IN RAT

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ABEDI JAMILEH; TUKMECHI AMIR; NEJATI VAHID; HOBBENAGHI RAHIM

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Journal: Journal of Isfahan Medical School Year:2014 | Volume:32 | Issue:291 Page(s): 1-13

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Title

PREVENTIVE IMPACTS OF SELENIUM ENRICHED YEAST ON LIVER AND ENZYME ACTIVITY AFTER COLORECTAL CANCER INDUCED IN RAT

Author(s)

ABEDI JAMILEH | TUKMECHI AMIR | NEJATI VAHID | HOBBENAGHI RAHIM | Issue Writer Certificate

Keywords

COLORECTAL CANCERQ2

DIMETHYL HYDRAZINEQ2

LIVER ENZYMESQ2

RATQ2

SACCHAROMYCES CEREVISIAEQ1

SELENIUMQ1

Abstract

Background: COLORECTAL CANCER is the most common cause of death in the world. More studies were done on using the probiotics and SELENIUM for cancer prevention. In this research LIVER ENZYMES changes (such as Alanine Aminotransferase, Asparate Aminotransferase and Alkaline Phosphatase) were assayed following dietary administration of SACCHAROMYCES CEREVISIAE (simple and SELENIUM enriched forms) in the RAT with COLORECTAL CANCER induced by DIMETHYL HYDRAZINE.Methods: Forty female RATs (200-250 g initial body weight) divided into five groups as healthy control, cancer control, simple form of yeast, SELENIUM and SELENIUM enriched yeast. All animals received carcinogenic agent (40 mg/kg body weight) twice weekly for five weeks, but except healthy control only received normal saline. SELENIUM group received 4 mg/ml of SELENIUM nitrate in water, SACCHAROMYCES CEREVISIAE was administered at 5×108 CFU/ml concentration with DIMETHYL HYDRAZINE in yeast group and finally, the last group received SELENIUM enriched yeast at the same concentration. At the end of forty weeks after DIMETHYL HYDRAZINE injection all animals were euthanized and blood samples were taken for enzymes assay.Findings: Although the mean of enzymes activity were higher at cancer control, but other groups significantly (P<0.05) showed lower enzymes activity. The most decrease of enzyme activity was seen at animals that received se-enriched yeast.Conclusion: The level of LIVER ENZYMES activity increase in COLORECTAL CANCER induced by DIMETHYL HYDRAZINE in RAT. SELENIUM enriched yeast administration in RAT could decrease the enzymes level and it prevent tissue damage after carcinogenic agent injection.

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APA: Copy

ABEDI, JAMILEH, TUKMECHI, AMIR, NEJATI, VAHID, & HOBBENAGHI, RAHIM. (2014). PREVENTIVE IMPACTS OF SELENIUM ENRICHED YEAST ON LIVER AND ENZYME ACTIVITY AFTER COLORECTAL CANCER INDUCED IN RAT. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 32(291), 1-13. SID. https://sid.ir/paper/51123/en

Vancouver: Copy

ABEDI JAMILEH, TUKMECHI AMIR, NEJATI VAHID, HOBBENAGHI RAHIM. PREVENTIVE IMPACTS OF SELENIUM ENRICHED YEAST ON LIVER AND ENZYME ACTIVITY AFTER COLORECTAL CANCER INDUCED IN RAT. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2014;32(291):1-13. Available from: https://sid.ir/paper/51123/en

IEEE: Copy

JAMILEH ABEDI, AMIR TUKMECHI, VAHID NEJATI, and RAHIM HOBBENAGHI, “PREVENTIVE IMPACTS OF SELENIUM ENRICHED YEAST ON LIVER AND ENZYME ACTIVITY AFTER COLORECTAL CANCER INDUCED IN RAT,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 32, no. 291, pp. 1–13, 2014, [Online]. Available: https://sid.ir/paper/51123/en

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