INCREASED RISK OF GASTRIC CANCER WITH DECREASED NUMBERS OF VNTR IN THE PROMOTER REGION OF RHOB GENE AND ASSESSMENT OF REPEATS NUMBER EFFECT ON EXPRESSION OF RHOB GENE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Shakeri Fariba; Mohammadinejad Parisa; Moghanibashi mansooriye Mohammad Mehdi

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Journal of Mashhad University of Medical Sciences Year:2017 | Volume:59 | Issue:6 Page(s): 293-304

Download Full-Text

Persian Verion

View:

496

Download:

Cites:

Information Journal Paper

Title

INCREASED RISK OF GASTRIC CANCER WITH DECREASED NUMBERS OF VNTR IN THE PROMOTER REGION OF RHOB GENE AND ASSESSMENT OF REPEATS NUMBER EFFECT ON EXPRESSION OF RHOB GENE

Author(s)

Shakeri Fariba | Mohammadinejad Parisa | Moghanibashi mansooriye Mohammad Mehdi | Issue Writer Certificate

Keywords

GASTRIC CANCERQ2

RHOB GENEQ1

VARIABLE NUMBER OF TANDEM REPEATSQ1

PROMOTERQ2

Abstract

Introduction: The RHOB GENE is one of the genes that are involved in cancers such as GASTRIC CANCER. This gene is contributed in cytoskeletal organization and cell trafficking and its expression is decreased in GASTRIC CANCER. There are a VNTR polymorphism in the PROMOTER of the RHOB GENE and in this study different genotypes of this VNTR was assessed with risk of GASTRIC CANCER, for the first time. Materials and Methods: In this study, the VNTR polymorphism of the PROMOTER region in 250 controls and 100 patients with GASTRIC CANCER, was assessed by PCR and electrophoresis on agarose gel. Then, the result was assessed by regression logistic and X2 tests. Also expression of the RHOB GENE in 19 controls with different repeats in PROMOTER region was compared by Real Time RT-PCR. Results: Our result showed the 1. 9 folds increase risk of GASTRIC CANCER with 8 and 9 repeats allele in comparison with 10 and 11 repeats (p=0. 044 ). But we found no association of number of repeats with expression of RHOB GENE (p=0. 605). Conclusion: The VNTR polymorphism of the RHOB GENE PROMOTER is associated with risk of GASTRIC CANCER and may be used for screening of GASTRIC CANCER if was confirmed by other studies.

Cites

No record.

References

No record.

Cite

APA: Copy

Shakeri, Fariba, Mohammadinejad, Parisa, & Moghanibashi mansooriye, Mohammad Mehdi. (2017). INCREASED RISK OF GASTRIC CANCER WITH DECREASED NUMBERS OF VNTR IN THE PROMOTER REGION OF RHOB GENE AND ASSESSMENT OF REPEATS NUMBER EFFECT ON EXPRESSION OF RHOB GENE. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 59(6 ), 293-304. SID. https://sid.ir/paper/51346/en

Vancouver: Copy

Shakeri Fariba, Mohammadinejad Parisa, Moghanibashi mansooriye Mohammad Mehdi. INCREASED RISK OF GASTRIC CANCER WITH DECREASED NUMBERS OF VNTR IN THE PROMOTER REGION OF RHOB GENE AND ASSESSMENT OF REPEATS NUMBER EFFECT ON EXPRESSION OF RHOB GENE. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;59(6 ):293-304. Available from: https://sid.ir/paper/51346/en

IEEE: Copy

Fariba Shakeri, Parisa Mohammadinejad, and Mohammad Mehdi Moghanibashi mansooriye, “INCREASED RISK OF GASTRIC CANCER WITH DECREASED NUMBERS OF VNTR IN THE PROMOTER REGION OF RHOB GENE AND ASSESSMENT OF REPEATS NUMBER EFFECT ON EXPRESSION OF RHOB GENE,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 59, no. 6 , pp. 293–304, 2017, [Online]. Available: https://sid.ir/paper/51346/en

Related Journal Papers