EFFECTS OF STATINS ON ARTERIAL BLOOD PRESSURE: A BLINDED CLINICAL RANDOMIZED TRIAL

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ROUHANI A.; AKBARI V.; GHAFARIAN SHIRAZI H.R.

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2010 | Volume:53 | Issue:2 Page(s): 79-83

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Title

EFFECTS OF STATINS ON ARTERIAL BLOOD PRESSURE: A BLINDED CLINICAL RANDOMIZED TRIAL

Author(s)

ROUHANI A. | AKBARI V. | GHAFARIAN SHIRAZI H.R. | Issue Writer Certificate

Keywords

BLOOD PRESSUREQ2

LDL CHOLESTEROLQ2

STATINSQ2

Abstract

Introduction: Now attention focuses on additional actions of STATINS which are independent from 3 hydroxy3 methylglutarylcoenzyme a reductase inhibition of them. The aim of this study was antihypertensive effect of STATINS.Materials and Methods: We performed a randomized, -blinded, placebo-controlled trial with equal allocation to simvastatin, 20 mg; or placebo for 6 months from December 2008 till June 2009. one hundred patients without known cardiovascular disease or diabetes mellitus, with low-density lipoprotein cholesterol screening levels of 130 to 190 mg/dL & BP <140/90 mm Hg ,had assessment of BP at rest in supine position (SBP and DBP, respectively) in monthly manner for two months. BLOOD PRESSURE values for placebo vs STATINS were compared.Results: The average of BLOOD PRESSURE in the statin group was124.8/81.12 and in the placebo was 123.75/87.125. STATINS modestly but significantly reduced BP relative to placebo, 115.5/71.9 (p= 0.02)) in one month after treatment. In placebo group BP reached to 124.25/84.25. However in the second month systolic BLOOD PRESSURE decreased but the diastolic BLOOD PRESSURE increased by one MM/HG (p= 0.5). In The placebo group BLOOD PRESSURE increased to 128.32/89.6.Conclusion: Reductions in SBP and DBP occurred with STATINS in normotensive and prehypertensive subjects. These modest effects may contribute to the reduced risk of stroke and cardiovascular events and the mortality reported on STATINS.

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APA: Copy

ROUHANI, A., AKBARI, V., & GHAFARIAN SHIRAZI, H.R.. (2010). EFFECTS OF STATINS ON ARTERIAL BLOOD PRESSURE: A BLINDED CLINICAL RANDOMIZED TRIAL. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 53(2), 79-83. SID. https://sid.ir/paper/51381/en

Vancouver: Copy

ROUHANI A., AKBARI V., GHAFARIAN SHIRAZI H.R.. EFFECTS OF STATINS ON ARTERIAL BLOOD PRESSURE: A BLINDED CLINICAL RANDOMIZED TRIAL. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;53(2):79-83. Available from: https://sid.ir/paper/51381/en

IEEE: Copy

A. ROUHANI, V. AKBARI, and H.R. GHAFARIAN SHIRAZI, “EFFECTS OF STATINS ON ARTERIAL BLOOD PRESSURE: A BLINDED CLINICAL RANDOMIZED TRIAL,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 53, no. 2, pp. 79–83, 2010, [Online]. Available: https://sid.ir/paper/51381/en

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