EFFICACY OF IL-2.RECEPTOR BLOCKERS IN LIVE DONOR RENAL TRANSPLANTATION

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NAZEMIAN F.; NAGHIBI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2006 | Volume:49 | Issue:93 Page(s): 247-252

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Information Journal Paper

Title

EFFICACY OF IL-2.RECEPTOR BLOCKERS IN LIVE DONOR RENAL TRANSPLANTATION

Author(s)

NAZEMIAN F. | NAGHIBI M. | Issue Writer Certificate

Keywords

ACUTE REJECTIONQ3

IL-2 RECEPTOR BLOCKERSQ3

RENAL TRANSPLANTATIONQ3

Abstract

Introduction: In the early post-transplantation period, ACUTE REJECTION is the major cause of graft failure. It is also one of the most important predictors for long-term graft survival following RENAL TRANSPLANTATION. This study was aimed to compare the rate of ACUTE REJECTION (AR) between patients receiving and those not receiving IL-2 RECEPTOR BLOCKERS for induction therapy.Materials and Methods: Ninty four patients undergoing RENAL TRANSPLANTATION from living donor were randomized into a prospective controlled trial. The patients were divided into two groups: D+ including 47 cases (26 men, 21 women with the mean age of 27.8+/-15.2 years) received Prednisolone, Cyclosporine, Mycophenolate Mofetil, plus Daclizumab and D- including 47 cases (28 men, 19women, mean age 28.4+/-12.8 years) received all above drugs except for aclizumab.They were matched considering the age of recipients and donors, recipient-donor relationship, underlying diseases and panel reactivity test status. Individual and laboratory data were recorded in the questionnaire. Data was analyzed using qualitive statistics and frequency distribution tables.Results: All patients completed the 6 month study. The acute tolerability for Daclizumab injection was good without any evidence of cytokine-release syndrome. D+ patients had less AR as compared with D-treated patients (17.02% vs. 8.51%). Graft survival at 6 months was higher with Daclizumab (100%) as compared with no induction (97.4%). Serious infection was seen in five cases (l 0.41%) in D+ group and 4 cases (8.33%) in control group. Patient death or malignancies did not occur in any group. Conclusion: Our study demonstrates that induction with Daclizumab results in reduction of early renal allograft rejection. The therapy with anti-IL-2R antibody is simple and is well tolerated.

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APA: Copy

NAZEMIAN, F., & NAGHIBI, M.. (2006). EFFICACY OF IL-2.RECEPTOR BLOCKERS IN LIVE DONOR RENAL TRANSPLANTATION. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 49(93), 247-252. SID. https://sid.ir/paper/51628/en

Vancouver: Copy

NAZEMIAN F., NAGHIBI M.. EFFICACY OF IL-2.RECEPTOR BLOCKERS IN LIVE DONOR RENAL TRANSPLANTATION. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;49(93):247-252. Available from: https://sid.ir/paper/51628/en

IEEE: Copy

F. NAZEMIAN, and M. NAGHIBI, “EFFICACY OF IL-2.RECEPTOR BLOCKERS IN LIVE DONOR RENAL TRANSPLANTATION,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 49, no. 93, pp. 247–252, 2006, [Online]. Available: https://sid.ir/paper/51628/en

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