EPIDEMIOLOGIC STUDY OF VIRUS GENOTYPES IN CHRONIC HEPATITIS C

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SARVGHAD S.M.R.; BOJDI AMIN; FAROKHNIA M.; JAVANIAN M.

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2006 | Volume:49 | Issue:93 Page(s): 309-314

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Title

EPIDEMIOLOGIC STUDY OF VIRUS GENOTYPES IN CHRONIC HEPATITIS C

Author(s)

SARVGHAD S.M.R. | BOJDI AMIN | FAROKHNIA M. | JAVANIAN M. | Issue Writer Certificate

Keywords

HCYQ2

GENOTYPEQ3

CHRONIC HEPATITIS CQ3

Abstract

Introduction: Hepatitis C is an emerging infection in Iran especially due to unsafe sharing between IVDUs. HCY GENOTYPE has an important role in clinical decision- making and drug therapy protocols. Up to now data is restricted and controversial in Iranian patients especially in Mashhad.Material and Methods: This descriptive study was done in the hospitals belonging to Mashhad University of Medical Sciences during the years 1382- 83. We included 63 patients that hepatitis C was confirmed in them by routine HCYRNA PCR method. The test was done in a single lab all by one person by primer-specific method. GENOTYPE of the virus was analyzed against risk factors in patients. Personal and laboratory data collected in a question are were analyzed by qualitive statistics.Results: Relative frequency of different GENOTYPEs and subtypes were: 3 (52.3%), 1(30.1%), 2(15.9%) and mixed (1.6%). The relative frequency of GENOTYPEs was significantly different in hemophilic patients from others (80% from GENOTYPE 1). Relative frequency of GENOTYPE 3 in thalasemics, hemodialysis patients, IVDUs and Blood donors was 66.7%, 66.6%, 55.44% and 46.18% respectively.Conclusion: According to genotyping results about 2/3 of patients are categorized in 'easy - to - treat group, but no discriminative factor could be estimated to differentiate this group of patients that need shorter courses of therapy with lower doses. So genotyping is still necessary for clinical decision making.

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APA: Copy

SARVGHAD, S.M.R., BOJDI, AMIN, FAROKHNIA, M., & JAVANIAN, M.. (2006). EPIDEMIOLOGIC STUDY OF VIRUS GENOTYPES IN CHRONIC HEPATITIS C. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 49(93), 309-314. SID. https://sid.ir/paper/51638/en

Vancouver: Copy

SARVGHAD S.M.R., BOJDI AMIN, FAROKHNIA M., JAVANIAN M.. EPIDEMIOLOGIC STUDY OF VIRUS GENOTYPES IN CHRONIC HEPATITIS C. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;49(93):309-314. Available from: https://sid.ir/paper/51638/en

IEEE: Copy

S.M.R. SARVGHAD, AMIN BOJDI, M. FAROKHNIA, and M. JAVANIAN, “EPIDEMIOLOGIC STUDY OF VIRUS GENOTYPES IN CHRONIC HEPATITIS C,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 49, no. 93, pp. 309–314, 2006, [Online]. Available: https://sid.ir/paper/51638/en

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