NEUROLOGICAL COMPLICATIONS OF HTLV-1 (REPORT OF TWO RARE CASES)

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EATEMADI M.M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2003 | Volume:46 | Issue:81 Page(s): 75-79

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Title

NEUROLOGICAL COMPLICATIONS OF HTLV-1 (REPORT OF TWO RARE CASES)

Author(s)

EATEMADI M.M. | Issue Writer Certificate

Keywords

HAM/TSP (HTLV-1)Q4

PCR (POLYMERASE CHAIN REACTION)Q2

MRIQ2

Abstract

HAM is an endemic neurologic disorder in many tropical and subtropical countries including North of Khorasan Province-Northeastern of Iran.The typical clinical presentation of this disease is a progressive myelopathic syndrome with spastic paraparesis, pain, paresthesia and difficulty in sphincteric control (4,9,10,11).In addition to myelopathy, HTLV-1 produces a lot of neurological syndromes such as cerebellar, bulbar, ALS-like, neuropathic and even myopathic syndrome (1,3,10,11). It's attractive that HTLV-1 could imitate neuroimaging (MRI) findings of degenerative (such as cerebellar and spinal atrophy) and demyelinating disease (Multiple Sclerosis); so it shares the differential diagnosis with many other neurological diseases (2,3). The diagnosis will be made too difficult because only a small proportion of HTLV-I infected individuals (estimated at 2-5%) develop a myelopathyor any other syndromes (10).Therefore, positive serologic tests Elisa for this virus in the blood alone are not a reason of HAM/TSP disease (7).In this article, we have presented two cases of this disease with respect to clinical presentations and neuroimaging (MRI) findings.First patient referred to our center with a predominantly cerebellar ataxia. The serologic tests of HTLV-1 in the CSF and blood documented the disease. MRI revealed cerebellar and spinal atrophy, second patient admitted with a typical myelopathic syndrome and CSF and blood serologic and PCR tests confirmed HAM/TSP with her.Brain T2-W MRI of this patient revealed a lot of hypersignal plaques. It is interesting that without any evidence of ouvert visual derangement, there was an increased P-I00 latency on VEP. So the relation between demyelinating disease (MS) and neurological features of HTLV-l (clinical and paraclinical, especially MRI findings) is attractive.

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APA: Copy

EATEMADI, M.M.. (2003). NEUROLOGICAL COMPLICATIONS OF HTLV-1 (REPORT OF TWO RARE CASES). MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 46(81), 75-79. SID. https://sid.ir/paper/51650/en

Vancouver: Copy

EATEMADI M.M.. NEUROLOGICAL COMPLICATIONS OF HTLV-1 (REPORT OF TWO RARE CASES). MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2003;46(81):75-79. Available from: https://sid.ir/paper/51650/en

IEEE: Copy

M.M. EATEMADI, “NEUROLOGICAL COMPLICATIONS OF HTLV-1 (REPORT OF TWO RARE CASES),” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 46, no. 81, pp. 75–79, 2003, [Online]. Available: https://sid.ir/paper/51650/en

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