APPLICATION OF NEW HISTOPATHOLOGIC METHODS IN IDENTIFING TYPES OF MEDULLARY THYROID CARCINOMA (MTC) IN TEN CASES

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MIRSADRAEI S.; FARZANDIYAN H.R.

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2001 | Volume:44 | Issue:72 Page(s): 91-101

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Title

APPLICATION OF NEW HISTOPATHOLOGIC METHODS IN IDENTIFING TYPES OF MEDULLARY THYROID CARCINOMA (MTC) IN TEN CASES

Author(s)

MIRSADRAEI S. | FARZANDIYAN H.R. | Issue Writer Certificate

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Abstract

Medullary Thyroid Carcinoma (MTC) refers to as a malignant neoplasm of the thyroid C cells. It occurs in a sporadic and an inherited form. MTC is the main part of the multiple endocrine neoplasia type 2 syndromes. MEN2A corresponds to an MTC associated with pheochromocytoma or hyperparathyroidism and MEN2B includes marfanoid habitus and ganglioneuromatosis in association with MTC. MTC without associated endocrinopathy may be hereditary (FMTC) or nonhereditary. The discovery of germline mutations in the RET proto-oncogene responsible for FMTC, MEN2A, and MEN2B associated with the presence of somatic mutations in RET codons in sporadic MTC, and in the several MTC from inherited disease has brought new perspectives.In the present retrospective study, ten cases of MTC out of ninety one thausands biopsies recieved in pathology department of Imam Reza Hospital Mashhad during past twenty years have been thoroughly surveyed.In this study, MTC consists 7.6% of all thyroid malignancies. Familial forms have been observed in two patients (20%) and sporadic MTC in the remaining cases (80%). Mean age is 48 years (27 to 60 years) in sporadic and 16 years (13 to 19 years) in familial cases. Male to female ratio (M/F) is 1/1.5. Neck lymphnode metastases have been observed in 30%, capsule in tumor periphery in one case (10%), amyloid at primary foci in 100% and at metastatic nodes in 67%. Several morphologic features of MTC such as angiosarcoma-like pattern and paraganglioma like pattern were at least focally observed. Papillary microcarcinoma was recovered as a concomitant finding with MTC in one patient. In ninety percent of cases, a positive immunostaining for chromogranin A and positive argyrophilic reaction were observed.

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APA: Copy

MIRSADRAEI, S., & FARZANDIYAN, H.R.. (2001). APPLICATION OF NEW HISTOPATHOLOGIC METHODS IN IDENTIFING TYPES OF MEDULLARY THYROID CARCINOMA (MTC) IN TEN CASES. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 44(72), 91-101. SID. https://sid.ir/paper/51774/en

Vancouver: Copy

MIRSADRAEI S., FARZANDIYAN H.R.. APPLICATION OF NEW HISTOPATHOLOGIC METHODS IN IDENTIFING TYPES OF MEDULLARY THYROID CARCINOMA (MTC) IN TEN CASES. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2001;44(72):91-101. Available from: https://sid.ir/paper/51774/en

IEEE: Copy

S. MIRSADRAEI, and H.R. FARZANDIYAN, “APPLICATION OF NEW HISTOPATHOLOGIC METHODS IN IDENTIFING TYPES OF MEDULLARY THYROID CARCINOMA (MTC) IN TEN CASES,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 44, no. 72, pp. 91–101, 2001, [Online]. Available: https://sid.ir/paper/51774/en

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