THE RELNTIONSHIP BETWEEN SERUM INTERLEUKIN-2RECEPTOR ALPHA (IL-2RA) LEVEL AND PROGNOSIS OF LEUKEMIC DISEASE (A PARAMETER FOR MONITORING)

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BONAKDARAN SH.; BARADARAN H.; MAZHAB Z.; REZAEEI A.

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2001 | Volume:44 | Issue:72 Page(s): 48-53

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Title

THE RELNTIONSHIP BETWEEN SERUM INTERLEUKIN-2RECEPTOR ALPHA (IL-2RA) LEVEL AND PROGNOSIS OF LEUKEMIC DISEASE (A PARAMETER FOR MONITORING)

Author(s)

BONAKDARAN SH. | BARADARAN H. | MAZHAB Z. | REZAEEI A. | Issue Writer Certificate

Keywords

IL-2RΑQ4

ACUTE LEUKEMIAQ3

PROGNOSISQ3

Abstract

Acute leukemia one of the most common hematologic malignancies. For monitoring of these patients, some parameters were used that IL-2RΑ is one of them. IL-2RΑ is an immunological marker on the surface of T lymphocytes and various types of leukemic cells that may increases in leukemic patients.This study was performed in 50 leukemic patients, 25 with ALL and 25 with AML (The mean age 27.6 yr). Serum IL-2RΑ was measured with ELISA method. The mean concentration of serum IL-2RΑ was 1909.2 pg/ml in leukemic patients and comparable with the healthy subjects (P<0.0001). It was 273pg/ml in control group.In addition the serum IL-2RΑ in ALL and AML patients were 2478.6pg/ml and 1339.7pg/ml respectively. This difference was significant (P<0.04).There is a significant difference for IL-2RΑ between patients with complete remission (889.5 pg/ml) and patients that had recurrence (2900 pg/m) or expired (2407.8 pg/ml) (P<0.002). That seems to be an important pattern.So, quantitative measurement of serum IL-2RΑ level is a remarkable parameter for PROGNOSIS in ACUTE LEUKEMIA that also determines the course of the disease.As the higher concentration of this membrane protein might be due to the higher expression on leukemic cell surfaces. Therefore monoclonal antibodies against IL-2RΑ (Anti CD 25) may prevent leukemic clones progression.

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APA: Copy

BONAKDARAN, SH., BARADARAN, H., MAZHAB, Z., & REZAEEI, A.. (2001). THE RELNTIONSHIP BETWEEN SERUM INTERLEUKIN-2RECEPTOR ALPHA (IL-2RA) LEVEL AND PROGNOSIS OF LEUKEMIC DISEASE (A PARAMETER FOR MONITORING). MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 44(72), 48-53. SID. https://sid.ir/paper/51777/en

Vancouver: Copy

BONAKDARAN SH., BARADARAN H., MAZHAB Z., REZAEEI A.. THE RELNTIONSHIP BETWEEN SERUM INTERLEUKIN-2RECEPTOR ALPHA (IL-2RA) LEVEL AND PROGNOSIS OF LEUKEMIC DISEASE (A PARAMETER FOR MONITORING). MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2001;44(72):48-53. Available from: https://sid.ir/paper/51777/en

IEEE: Copy

SH. BONAKDARAN, H. BARADARAN, Z. MAZHAB, and A. REZAEEI, “THE RELNTIONSHIP BETWEEN SERUM INTERLEUKIN-2RECEPTOR ALPHA (IL-2RA) LEVEL AND PROGNOSIS OF LEUKEMIC DISEASE (A PARAMETER FOR MONITORING),” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 44, no. 72, pp. 48–53, 2001, [Online]. Available: https://sid.ir/paper/51777/en

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