ASSESSMENT OF BILIRUBIN TO ALBUMIN RATIO AS A CRITERION FOR EXCHANGE TRANSFUSION IN SEVERE NEONATAL HYPERBILIRUBINEMIA

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AHMADPOUR KACHO MOUSA; ZAHEDPASHA YADOLLAH; PEYDAYESH SIAMAK; MAZLOOMI AAZAMOSSAT

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2011 | Volume:54 | Issue:3 Page(s): 137-142

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Title

ASSESSMENT OF BILIRUBIN TO ALBUMIN RATIO AS A CRITERION FOR EXCHANGE TRANSFUSION IN SEVERE NEONATAL HYPERBILIRUBINEMIA

Author(s)

AHMADPOUR KACHO MOUSA | ZAHEDPASHA YADOLLAH | PEYDAYESH SIAMAK | MAZLOOMI AAZAMOSSAT | Issue Writer Certificate

Keywords

BILIRUBIN-ALBUMIN RATIOQ2

EXCHANGE TRANSFUSIONQ2

NEONATAL JAUNDICEQ3

Abstract

Introduction: Total Serum Bilirubin level (TSB) has been the gold standard indicator for EXCHANGE TRANSFUSION (ET) in the neonates for many years. This study was designed to assess the bilirubin/albumin (B/A) ratio as an indicator for ET in comparison with TSB.Materials and Methods: In the NICU and newborn services at Amirkola Children’s Hospital (ACH) in the north of Iran, 90 neonates in 3 groups were selected. The first group was 30 neonates who required EXCHANGE TRANSFUSION (ET), because of severe hyperbilirubinemia (HB) based on the TSB according to the ACH protocol .The second group was 30 neonates, treated with phototherapy due to pathologic HB and the Other 30 neonates had only physiologic NEONATAL JAUNDICE. Blood samples were checked for serum bilirubin, albumin and B/A ratio in addition to the routine lab tests for HB. Sensitivity, specificity, negative predictive value, positive predictive value, and relative risk were assessed for B/A ratio as a determinant to do ET.Results: The mean±SD of B/A ratio was 6.0847±0.9870 in blood exchange group, 4.1680±0.5480 in phototherapy group and 1.7677±0.5061 in healthy neonate group. “Cut off level” of B/A ratio calculated to do ET was 4.50.The B/A ratio of 4.5 has a “positive predictive value” of 75% and a “negative predictive value” of 100%.Conclusion: A B/A ratio equal to 4.5 among newborns Who required EXCHANGE TRANSFUSION has a high value as a criterion to do ET, although further study is required to recommend it alone in clinical practice. So we recommend doing B/A ratio in accompaniment with TSB as an adjunctive test.

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APA: Copy

AHMADPOUR KACHO, MOUSA, ZAHEDPASHA, YADOLLAH, PEYDAYESH, SIAMAK, & MAZLOOMI, AAZAMOSSAT. (2011). ASSESSMENT OF BILIRUBIN TO ALBUMIN RATIO AS A CRITERION FOR EXCHANGE TRANSFUSION IN SEVERE NEONATAL HYPERBILIRUBINEMIA. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 54(3), 137-142. SID. https://sid.ir/paper/51812/en

Vancouver: Copy

AHMADPOUR KACHO MOUSA, ZAHEDPASHA YADOLLAH, PEYDAYESH SIAMAK, MAZLOOMI AAZAMOSSAT. ASSESSMENT OF BILIRUBIN TO ALBUMIN RATIO AS A CRITERION FOR EXCHANGE TRANSFUSION IN SEVERE NEONATAL HYPERBILIRUBINEMIA. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;54(3):137-142. Available from: https://sid.ir/paper/51812/en

IEEE: Copy

MOUSA AHMADPOUR KACHO, YADOLLAH ZAHEDPASHA, SIAMAK PEYDAYESH, and AAZAMOSSAT MAZLOOMI, “ASSESSMENT OF BILIRUBIN TO ALBUMIN RATIO AS A CRITERION FOR EXCHANGE TRANSFUSION IN SEVERE NEONATAL HYPERBILIRUBINEMIA,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 54, no. 3, pp. 137–142, 2011, [Online]. Available: https://sid.ir/paper/51812/en

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