THE EFFECT OF ORAL VITAMIN E ON RENAL ANEMIA IN CHRONIC HEMODIALYSIS CHILDREN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHANE F.; MODARESI A.R.; ESMAEILI M.; KHAJEH DALOUEI M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2006 | Volume:49 | Issue:91 Page(s): 27-34

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

2,397

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF ORAL VITAMIN E ON RENAL ANEMIA IN CHRONIC HEMODIALYSIS CHILDREN

Author(s)

GHANE F. | MODARESI A.R. | ESMAEILI M. | KHAJEH DALOUEI M. | Issue Writer Certificate

Keywords

OXIDATIVE STRESSQ2

END - STAGE RENAL DISEASEQ3

HEMODIALYSISQ3

VITAMIN EQ2

ANEMIAQ3

Abstract

Introduction: Renal ANEMIA is one of the most frequently observed complications in patients undergoing chronic HEMODIALYSIS (HD). Reduced red blood cell survival due to oxidative damage is one of causes of ANEMIA in these patients. VITAMIN E (alpha - tocopherol) is a natural biological antioxidant, which protects red cells from these effects of reactive oxygen metabolites and could be useful as a collateral therapy for ANEMIA in HD patients. The aim of the present study was to investigate the potential beneficial effect of anti oxidant VITAMIN E supplementation (oral) on renal ANEMIA and to find out whether this improvement mechanism is attributable to the enhanced hematopoietic function or to prolonged RBC life Material and methods: This clinical trial study included (8 cases with mean age 14±2.9 years and 7 controls with mean age 14±2.7 years) stable children on chronic HEMODIALYSIS, at HEMODIALYSIS center in Sheikh Children Hospital- Mashhad. At the time of entry, there was no evidence of iron deficiency or history of blood transfusion. All of children (case and control) received subcutaneous erythropoietin (EPO) 120±80 u/kg/BW/week, Folic acid 1 mg/day and Iron 1-2 mg/kg/day. Oral VITAMIN E 200 u/day for 3 months was prescribed to cases only. Laboratory parameters determined at the beginning of the study were: Iron, Ferritin, Transferrin, Total Iron binding capacity, Hemoglobin (Hb), Hematocrit, Reticulocyte count and peripheral blood smear. Hb and HCT were checked every month during the study and the results were compared to those obtained earlier.Results: Prescription of oral VITAMIN E for 3 months resulted in significantly higher levels of Hb and Hct in cases compared to those in controls (11.4±1.7 vs. 10.1±1.9Hb and 35.3±5vs. 31.3± 6 Htc, P< 0.05).Conclusion: Antioxidant VITAMIN E supplementation improves renal ANEMIA by decrease of OXIDATIVE STRESS and RBC life span in HEMODIALYSIS patients.

Cites

No record.

References

No record.

Cite

APA: Copy

GHANE, F., MODARESI, A.R., ESMAEILI, M., & KHAJEH DALOUEI, M.. (2006). THE EFFECT OF ORAL VITAMIN E ON RENAL ANEMIA IN CHRONIC HEMODIALYSIS CHILDREN. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 49(91), 27-34. SID. https://sid.ir/paper/51822/en

Vancouver: Copy

GHANE F., MODARESI A.R., ESMAEILI M., KHAJEH DALOUEI M.. THE EFFECT OF ORAL VITAMIN E ON RENAL ANEMIA IN CHRONIC HEMODIALYSIS CHILDREN. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;49(91):27-34. Available from: https://sid.ir/paper/51822/en

IEEE: Copy

F. GHANE, A.R. MODARESI, M. ESMAEILI, and M. KHAJEH DALOUEI, “THE EFFECT OF ORAL VITAMIN E ON RENAL ANEMIA IN CHRONIC HEMODIALYSIS CHILDREN,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 49, no. 91, pp. 27–34, 2006, [Online]. Available: https://sid.ir/paper/51822/en

Related Journal Papers