ASSOCIATION BETWEEN SERUM HSP27 IN BEHCET’S DISEASE PATIENTS, WITH AND WITHOUT UVEITIS

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MIRFEYZI ZAHRA; ZEREHSAZ ZEID; ESMAEELI HABIBOLAH; SAHEBARI MARYAM

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2014 | Volume:57 | Issue:6 Page(s): 744-750

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Title

ASSOCIATION BETWEEN SERUM HSP27 IN BEHCET’S DISEASE PATIENTS, WITH AND WITHOUT UVEITIS

Author(s)

MIRFEYZI ZAHRA | ZEREHSAZ ZEID | ESMAEELI HABIBOLAH | SAHEBARI MARYAM | Issue Writer Certificate

Keywords

BEHCET SYNDROMEQ2

HSP27Q3

UVEITISQ3

Abstract

Introduction: Behcet's disease (BD) is an autoimmune disease, which can affect multiple systems in the human body. Recently, the effects of serum heat shock protein (HSP27) level and antibodies against it have been demonstrated in Behcet's etiology and pathogenesis. This study aimed to determine the serum levels of HSP27 and high-sensitivity C-reactive protein (hs-CRP) in BD, and their relationship with UVEITIS in these patients.Materials and Methods: In the current cross-sectional study, the sample size was calculated as 94 individuals. The subjects were divided into three groups: patients with Behcet’s UVEITIS (BD+U), BD patients without UVEITIS (BD-U), and those with idiopathic UVEITIS. The serum levels of HSP27 and hs-CRP were compared among the three groups. The serum HSP27 level was measured, using ELISA technique.Results: The mean serum HSP27 level was 28.81±7.593, 31.78±6.841, and 24.07±7.095 in BD-U, BD+U, and idiopathic UVEITIS patients, respectively. These results indicated that there was a significant difference between the three groups regarding serum HSP27 level (F=8.118) (P=0.001).Conclusion: According to the results, there was a significant difference in HSP27 level in BD+U and idiopathic groups; therefore, serum HSP27 level can be a sensitive marker for the diagnosis of Behçet's UVEITIS.

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APA: Copy

MIRFEYZI, ZAHRA, ZEREHSAZ, ZEID, ESMAEELI, HABIBOLAH, & SAHEBARI, MARYAM. (2014). ASSOCIATION BETWEEN SERUM HSP27 IN BEHCET’S DISEASE PATIENTS, WITH AND WITHOUT UVEITIS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 57(6), 744-750. SID. https://sid.ir/paper/51857/en

Vancouver: Copy

MIRFEYZI ZAHRA, ZEREHSAZ ZEID, ESMAEELI HABIBOLAH, SAHEBARI MARYAM. ASSOCIATION BETWEEN SERUM HSP27 IN BEHCET’S DISEASE PATIENTS, WITH AND WITHOUT UVEITIS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;57(6):744-750. Available from: https://sid.ir/paper/51857/en

IEEE: Copy

ZAHRA MIRFEYZI, ZEID ZEREHSAZ, HABIBOLAH ESMAEELI, and MARYAM SAHEBARI, “ASSOCIATION BETWEEN SERUM HSP27 IN BEHCET’S DISEASE PATIENTS, WITH AND WITHOUT UVEITIS,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 57, no. 6, pp. 744–750, 2014, [Online]. Available: https://sid.ir/paper/51857/en

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