THE EFFECT OF TOPIRAMATE IN TREATMENT OF CHILDREN WITH INTRACTABLE EPILEPSY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AKHOUNDIAN J.; JAFARI V.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Journal of Mashhad University of Medical Sciences Year:2007 | Volume:50 | Issue:96 Page(s): 143-148

Download Full-Text

Persian Verion

View:

4,032

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF TOPIRAMATE IN TREATMENT OF CHILDREN WITH INTRACTABLE EPILEPSY

Author(s)

AKHOUNDIAN J. | JAFARI V. | Issue Writer Certificate

Keywords

INTRACTABLE SEIZUREQ3

TOPIRAMATEQ2

DRUG RESISTANT EPILEPSYQ3

Abstract

Introduction: 0.5 to 1% of children are epileptic, and 25% of these patients are resistant to therapy. Uncontrolled seizures produce multiple impairments in personal and social life of the patient. Any reduction in seizure number or obviation of them will raise quality of life and can refine educational, occupational and familial situation of the patient. Multiple studies in adults and children have shown efficacy of TOPIRAMATE as mono or add-on therapy in reduction of seizures. The aim of this study was to evaluate the effects of this drug on intractable epilepsy. Material and Methods: This study was done as a clinical trial in Pediatric Neurology Clinic of Ghaem Hospital in the year 2005. 24 drug resistant epileptic patients entered the study. In all of them TOPIRAMATE administered as add-on therapy in a daily dose of 3 mg/kg and increased up to 9 mg/kg, in a therapy period of at least two months. Any change in seizure number, probable side effects of drug consumption, and patient’s individual data was evaluated and recorded in a questionnaire and analyzed by descriptive statistics and frequency distribution tables.Result: Mean of seizure number of patients was 119.95per month, which reduced to 53.41 after receiving TOPIRAMATE. In 25% of patients seizures resolved completely and in 20.9% of them no improvement was noted. The results of this study implied the efficacy of TOPIRAMATE in reduction of seizure number.Conclusion: TOPIRAMATE and other new antiepileptic drugs due to their effectiveness and lesser adverse effects can be used progressively, and in many cases they can be substituted for older antiepileptic agents.

Cites

No record.

References

No record.

Cite

APA: Copy

AKHOUNDIAN, J., & JAFARI, V.. (2007). THE EFFECT OF TOPIRAMATE IN TREATMENT OF CHILDREN WITH INTRACTABLE EPILEPSY. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 50(96), 143-148. SID. https://sid.ir/paper/51942/en

Vancouver: Copy

AKHOUNDIAN J., JAFARI V.. THE EFFECT OF TOPIRAMATE IN TREATMENT OF CHILDREN WITH INTRACTABLE EPILEPSY. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;50(96):143-148. Available from: https://sid.ir/paper/51942/en

IEEE: Copy

J. AKHOUNDIAN, and V. JAFARI, “THE EFFECT OF TOPIRAMATE IN TREATMENT OF CHILDREN WITH INTRACTABLE EPILEPSY,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 50, no. 96, pp. 143–148, 2007, [Online]. Available: https://sid.ir/paper/51942/en

Related Journal Papers