IMMUNOPATHOGENESIS OF BRUCELLOSIS

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PANAHI MAHMOOD

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Journal Paper

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2010 | Volume:53 | Issue:3 Page(s): 185-188

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Information Journal Paper

Title

IMMUNOPATHOGENESIS OF BRUCELLOSIS

Author(s)

PANAHI MAHMOOD | Issue Writer Certificate

Keywords

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Abstract

Brucellosis, is a common zoonosis in developing countries, where it undermines animal health and productivity. Brucella organisms invade cells of Reticuloendothelial system. Cytokines play an important role in inflammation. Brucella organisms induce a variety of prointlamatory cytokines such as IL-1 Beta, IL-6, IL-12 and TNF alpha, Brucella organisms induce the production of IL-10, a cytokine with ability of down regulation pro inflammatory process or an anti-inflamatory cytokine. IFN-gamma a crucial cytokine involved in immunity of Brucella, a Th-1 cytokine with stimulation activity of Bactericidal function in Macrophages. Th 1 T.Cell production of IFN-gamma activates Macrophages to kill interacellular Bacteria. Th 2 cells produce IL-4, IL-5, IL-13, IL-9, IL 10 and IL-25.Brucella Organisms have evolved Mechanisms to escape Neutrophil and antibody- mediated Immune defenses. Phagocytic cells entering is the most effective escape mechanism and in this condition The host cell becomes a protective defencse against exatera cel1ular anti-Microbial defenses. In diagnosis of Brucel1a infection serologic test is not a gold standard diagnostic assay, Regarding false positive and false negative serologic tests. Blood and Bone marrow culture and tissue PCR are strong tests and have high specificity and sencibility values.

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APA: Copy

PANAHI, MAHMOOD. (2010). IMMUNOPATHOGENESIS OF BRUCELLOSIS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 53(3), 185-188. SID. https://sid.ir/paper/52136/en

Vancouver: Copy

PANAHI MAHMOOD. IMMUNOPATHOGENESIS OF BRUCELLOSIS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;53(3):185-188. Available from: https://sid.ir/paper/52136/en

IEEE: Copy

MAHMOOD PANAHI, “IMMUNOPATHOGENESIS OF BRUCELLOSIS,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 53, no. 3, pp. 185–188, 2010, [Online]. Available: https://sid.ir/paper/52136/en

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