AN AVALUATION OF THE CORRELATION BETWEEN SHORT STATURE AND ENDOCRINOPATHY IN THALASSEMIA MAJOR PATIENTS (NON-COMMUNICABLE PEDIATRIC DISEASES RESEARCH CENTER, BABOL UNIVERSITY OF MEDICAL SCIENCES)

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ESHRAGHI PEIMAN; MEHRABANI TABARI SANAZ; MOHSENI ATEFEH

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2012 | Volume:55 | Issue:1 Page(s): 7-14

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Title

AN AVALUATION OF THE CORRELATION BETWEEN SHORT STATURE AND ENDOCRINOPATHY IN THALASSEMIA MAJOR PATIENTS (NON-COMMUNICABLE PEDIATRIC DISEASES RESEARCH CENTER, BABOL UNIVERSITY OF MEDICAL SCIENCES)

Author(s)

ESHRAGHI PEIMAN | MEHRABANI TABARI SANAZ | MOHSENI ATEFEH | Issue Writer Certificate

Keywords

ENDOCRINOPATHYQ3

FERRITINQ3

SHORT STATUREQ3

THALASSEMIA MAJORQ2

Abstract

Introduction: THALASSEMIA MAJOR is a hereditary anemia that becomes blood transfusion dependent. Iron overload consequence leads to multiple organ dysfunction and ENDOCRINOPATHY. So deferoxamine (desferal) is used for chelation therapy. The aim of this study was to evaluate the growth rate of these patients and its correlation with endocrine complications and determine the role of secondary iron overload in these situations.Materials and Methods: This cross-sectional study was performed for a year (2010) on 280 patients (aged 3.5-56 years) who received blood transfusion and chelation therapy at Amir kola Thalassemia Center. After basic evaluations, determination of height standard deviation, they were divided by serum FERRITIN level into two groups (good and poorly controlled). They were evaluated for hypothyroidism, diabetes mellitus, hypoparathyroidism and hypogonadism. Next, data were analyzed. A p<0.05 was considered significant.Results: From 280 patients with mean age of 19.6±8.5 years, 161 (57.5%) cases were female, SHORT STATURE (<-2 SDS) was present in 90 cases (32.1%). Their mean height was 151.4±17.3 cm. 162 cases (57.9%) had ENDOCRINOPATHY. There was a relationship between SHORT STATURE and hypoparathyroidism (p=0.009) and hypogonadism (p=0.005) and also diabetes mellitus (p=0.003), but no relationship was found between SHORT STATURE and hypothyroidism (p=1.000) and serum FERRITIN level (p=0.091).Conclusion: According to higher prevalence of hypoparathyroidism, hypogonadism and diabetes mellitus in SHORT STATUREd thalassemic patients, screening should be done for such disorders with more sensitivity in these patients.

Cites

THE PREVALENCE OF HYPOGONADISM IN PATIENTS WITH THALASSEMIA MAJOR IN IRAN: A SYSTEMATIC REVIEW AND META-ANALYSIS STUDY

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APA: Copy

ESHRAGHI, PEIMAN, MEHRABANI TABARI, SANAZ, & MOHSENI, ATEFEH. (2012). AN AVALUATION OF THE CORRELATION BETWEEN SHORT STATURE AND ENDOCRINOPATHY IN THALASSEMIA MAJOR PATIENTS (NON-COMMUNICABLE PEDIATRIC DISEASES RESEARCH CENTER, BABOL UNIVERSITY OF MEDICAL SCIENCES). MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 55(1), 7-14. SID. https://sid.ir/paper/52172/en

Vancouver: Copy

ESHRAGHI PEIMAN, MEHRABANI TABARI SANAZ, MOHSENI ATEFEH. AN AVALUATION OF THE CORRELATION BETWEEN SHORT STATURE AND ENDOCRINOPATHY IN THALASSEMIA MAJOR PATIENTS (NON-COMMUNICABLE PEDIATRIC DISEASES RESEARCH CENTER, BABOL UNIVERSITY OF MEDICAL SCIENCES). MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;55(1):7-14. Available from: https://sid.ir/paper/52172/en

IEEE: Copy

PEIMAN ESHRAGHI, SANAZ MEHRABANI TABARI, and ATEFEH MOHSENI, “AN AVALUATION OF THE CORRELATION BETWEEN SHORT STATURE AND ENDOCRINOPATHY IN THALASSEMIA MAJOR PATIENTS (NON-COMMUNICABLE PEDIATRIC DISEASES RESEARCH CENTER, BABOL UNIVERSITY OF MEDICAL SCIENCES),” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 55, no. 1, pp. 7–14, 2012, [Online]. Available: https://sid.ir/paper/52172/en

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