EVALUATION OF CARBAMAZEPINE AND OXCARBAZEPINE ON TINNITUS (OTOLARYNGOLOGY, HEAD & NECK SURGERY RESEARCH CENTER, GUILAN UNIVERSITY OF MEDICAL SCIENCES)

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GERAMI HOOSHANG; NEMATI SHADMAN; SABERI ALIA; NAGHAVI EBRAHIM; KAZEMNEJAD EHSAN; SADEGHI ALI AKBAR; GERAMISERESHT MARJAN

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:55 | Issue:1 Page(s): 46-51

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Title

EVALUATION OF CARBAMAZEPINE AND OXCARBAZEPINE ON TINNITUS (OTOLARYNGOLOGY, HEAD & NECK SURGERY RESEARCH CENTER, GUILAN UNIVERSITY OF MEDICAL SCIENCES)

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Keywords

ANTICONVULSANTQ2

CARBAMAZEPINEQ2

OXCARBAZEPINEQ3

TINNITUSQ2

Abstract

Introduction: Due to multiplicity of TINNITUS etiologies and the lack of accurate knowledge about its exact mechanism, it is still a challenge to find an effective treatment. The objective of this study was an evaluation of CARBAMAZEPINE and OXCARBAZEPINE effect on TINNITUS in patients' referred to Amiralmomenin Hospital Rasht-Iran.Materials and Methods: In a randomized double-blind clinical trial, a total of 57 patients (23 to 71 years old) with chronic nonpulsatile TINNITUS were treated in three separate groups with CARBAMAZEPINE (300-600mg), OXCARBAZEPINE (450-900 mg) and placebo for 12 weeks. In the early stages of the study, physical examination and nessecary laboratory tests, audiometry tests, complementation of Visual Analogue Scale (VAS) and TINNITUS Severity Index (TSI) were performed. At the end of 8th and 12th weeks, VAS and TSI questionnaire were completed again.Results: Among 51 patients (28 male, 23 female) who completed the trial course, according to VAS, CARBAMAZEPINE, OXCARBAZEPINE and placebo decreased severity of TINNITUS in 56.6%, 46.2% and 38.5% of cases respectively. Decrement in TINNITUS severity on the basis of TSI in the three mentioned groups were 61.1%, 58.8% and 50% respectively. CARBAMAZEPINE and OXCARBAZEPINE were not more effective than placebo in subsiding TINNITUS on the basis of VAS and TSI. Conclusion: CARBAMAZEPINE and its analouge, OXCARBAZEPINE are effective in decreasing TINNITUS severity, but they are not significantly more effective than placebo.

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APA: Copy

GERAMI, HOOSHANG, NEMATI, SHADMAN, SABERI, ALIA, NAGHAVI, EBRAHIM, KAZEMNEJAD, EHSAN, SADEGHI, ALI AKBAR, & GERAMISERESHT, MARJAN. (2012). EVALUATION OF CARBAMAZEPINE AND OXCARBAZEPINE ON TINNITUS (OTOLARYNGOLOGY, HEAD & NECK SURGERY RESEARCH CENTER, GUILAN UNIVERSITY OF MEDICAL SCIENCES). MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 55(1), 46-51. SID. https://sid.ir/paper/52174/en

Vancouver: Copy

GERAMI HOOSHANG, NEMATI SHADMAN, SABERI ALIA, NAGHAVI EBRAHIM, KAZEMNEJAD EHSAN, SADEGHI ALI AKBAR, GERAMISERESHT MARJAN. EVALUATION OF CARBAMAZEPINE AND OXCARBAZEPINE ON TINNITUS (OTOLARYNGOLOGY, HEAD & NECK SURGERY RESEARCH CENTER, GUILAN UNIVERSITY OF MEDICAL SCIENCES). MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;55(1):46-51. Available from: https://sid.ir/paper/52174/en

IEEE: Copy

HOOSHANG GERAMI, SHADMAN NEMATI, ALIA SABERI, EBRAHIM NAGHAVI, EHSAN KAZEMNEJAD, ALI AKBAR SADEGHI, and MARJAN GERAMISERESHT, “EVALUATION OF CARBAMAZEPINE AND OXCARBAZEPINE ON TINNITUS (OTOLARYNGOLOGY, HEAD & NECK SURGERY RESEARCH CENTER, GUILAN UNIVERSITY OF MEDICAL SCIENCES),” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 55, no. 1, pp. 46–51, 2012, [Online]. Available: https://sid.ir/paper/52174/en

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