THE COMPARISON BETWEEN FLUOXETIN AND CLOMIPRAMIN IN CHILDREN AND ADOLESCENTS WITH OBSESSIVE – COMPULSIVE DISORDER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SOLTANIFAR A.; ABD ELAHIAN E.; NASIRAEI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2007 | Volume:50 | Issue:97 Page(s): 315-320

Download Full-Text

Persian Verion

View:

11,177

Download:

Cites:

Information Journal Paper

Title

THE COMPARISON BETWEEN FLUOXETIN AND CLOMIPRAMIN IN CHILDREN AND ADOLESCENTS WITH OBSESSIVE – COMPULSIVE DISORDER

Author(s)

SOLTANIFAR A. | ABD ELAHIAN E. | NASIRAEI A. | Issue Writer Certificate

Keywords

OCDQ3

FLUOXETINQ3

CLOMIPRAMINQ2

Abstract

Introduction: Obsessive compulsive disorder (OCD) in children and adolescents is apparently a much more common disorder than what believed before.Most studies concerning treatment of OCD has been based on experience from adult patients. Only a few controlled trials using medication in children with OCD have been conducted. The present study compared the efficacy of CLOMIPRAMIN and FLUOXETIN in children and adolescents with OCD.Materials and Methods: This double blind clinical trial, performed from 2002 for one year, at Mashhad Pediatric Psychiatry, compared the efficacy of CLOMIPRAMIN and FLUOXETIN in 26 OCD children and adolescents, randomized into two groups. Efficacy assessments included the child version of Yale -Brown obsessive compulsive scale (CYBOCS) and NIMH Global rating scale and Maudsely questionnaire. The study took 8 weeks long and assessments were accomplished before the treatment, 4weeks and 8weeks after it. CLOMIPRAMIN was used 10mg/dayin patients over 20 kg weight and increased to 50 mg /day in one week. Dosage then rose up to 3 mg/kg based on the clinician's decision. FLUOXETIN was started with 10 mg/day and reached 20 mg/day in one week.Then titrated up to 1mg/kg/day based on clinical judgment of clinician. Three patients were dropped out because of different reasons and one patient discontinued using CLOMIPRAMIN because of its adverse effects. Data were collected and analyzed using the descriptive statistics and Mann withney test.Results: There was a significant difference in the efficacy of the two drugs based on total CYBOCS score and the score of obsessions, compulsions and FLUOXETINe was more effective than CLOMIPRAMIN. However, there was no conciderable variation between them based on maudsely questionnaire, its subscales scores and NIMH Global rating scale score. The CYBOCS total score decreased to 44% and 49% after 8 weeks of CLOMIPRAMIN and FLUOXETIN consumption; respectively.Conclusion: The results suggested that FLUOXETIN is at least as effective as CLOMIPRAMIN in short term treatment of children and adolescents with OCD. More studies with larger sample size and longer time for follow-up are recommended.

Cites

A META-ANALYSIS ON THE EFFECTIVENESS OF DRUG THERAPY IN IMPROVING OBSESSIVE-COMPULSIVE DISORDER SYMPTOMS

References

No record.

Cite

APA: Copy

SOLTANIFAR, A., ABD ELAHIAN, E., & NASIRAEI, A.. (2007). THE COMPARISON BETWEEN FLUOXETIN AND CLOMIPRAMIN IN CHILDREN AND ADOLESCENTS WITH OBSESSIVE – COMPULSIVE DISORDER . MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 50(97), 315-320. SID. https://sid.ir/paper/52338/en

Vancouver: Copy

SOLTANIFAR A., ABD ELAHIAN E., NASIRAEI A.. THE COMPARISON BETWEEN FLUOXETIN AND CLOMIPRAMIN IN CHILDREN AND ADOLESCENTS WITH OBSESSIVE – COMPULSIVE DISORDER . MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;50(97):315-320. Available from: https://sid.ir/paper/52338/en

IEEE: Copy

A. SOLTANIFAR, E. ABD ELAHIAN, and A. NASIRAEI, “THE COMPARISON BETWEEN FLUOXETIN AND CLOMIPRAMIN IN CHILDREN AND ADOLESCENTS WITH OBSESSIVE – COMPULSIVE DISORDER ,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 50, no. 97, pp. 315–320, 2007, [Online]. Available: https://sid.ir/paper/52338/en

Related Journal Papers