A STUDY OF HEMATOLOGIC, HEPATIC AND RENAL SIDE EFFECTS OF INTRAMUSCULAR INJECTION OF MEGLUMINE ANTIMONIATE (GLUCANTIME) ON PATIENTS WITH CUTANEOUS LEISHMANIASIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MALEKI MASOUD; JAVIDI Z.; TAHERI A.R.; EBRAHIMIRAD M.; RASTI MASOUD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Journal of Mashhad University of Medical Sciences Year:2007 | Volume:50 | Issue:97 Page(s): 269-274

Download Full-Text

Persian Verion

View:

8,654

Download:

Cites:

Information Journal Paper

Title

A STUDY OF HEMATOLOGIC, HEPATIC AND RENAL SIDE EFFECTS OF INTRAMUSCULAR INJECTION OF MEGLUMINE ANTIMONIATE (GLUCANTIME) ON PATIENTS WITH CUTANEOUS LEISHMANIASIS

Author(s)

Keywords

GLUCANTIMQ3

CUTANEOUS LEISHMANIASISQ3

HEMATOLOGIC SIDE EFFECTQ3

HEPATIC SIDE EFFECTQ3

RENAL SIDE EFFECTQ3

Abstract

Introduction: CUTANEOUS LEISHMANIASISis an endemic disease in many countries that is caused by different species of Leishmania. Nowadays, standard medication for leishmaniasis is pentavalent antimony compounds that are used intramuscular or intralesional. Though, they are drugs of choice, there are limitations such as hematologic, hepatic, renal and cardiac side effects. This study reviewed hematological, hepatic, and RENAL SIDE EFFECTs of GLUCANTIM.Material and Methods: The present work was a pre- and post- treatment study on 35 patients with CUTANEOUS LEISHMANIASIS referred to Dermatology Department, Imam Reza Hospital, Mashhad.Their disease was confirmed by direct smear. The patients were treated with intramuscular GLUCANTIMe 60mglkg daily for 20 days. Complete blood count (CBC, diff), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), blood urea nitrogen (BUN), creatinine (Cr) were evaluted at 3 times: before treatment, on the 20th day of treatment course (last day of injection), and a month after the end of treatment. Demographic, laboratory and treatment results, and drug complications were recorded in a questionnaire. Data were analyzed by descriptive statistics.Results: Of 35 patients in this study, 26 completed the course. Red blood cell count, hemoglobin and hematocrit levels significantly reduced (P<0.05), but no significant difference was shown in white blood cell and platelet count. The increase of serum SGOT and SGPT levels were considerable (P<0.05). Elevated serum levels of Cr and BUN observed in 11.5% and 34.6% of patients, respectively; and RENAL SIDE EFFECTs were more common in females than in males (64% in females VS 10%in males).Conclusion: Systemic GLUCANTIMe is associated with hematologic, hepatic, and RENAL SIDE EFFECTs. Therefore, evaluation of hematologic, hepatic and renal statement in patients receiving GLUCANTIM, before and during treatment is suggested.

Cites

No record.

References

Cite

APA: Copy

MALEKI, MASOUD, JAVIDI, Z., TAHERI, A.R., EBRAHIMIRAD, M., & RASTI, MASOUD. (2007). A STUDY OF HEMATOLOGIC, HEPATIC AND RENAL SIDE EFFECTS OF INTRAMUSCULAR INJECTION OF MEGLUMINE ANTIMONIATE (GLUCANTIME) ON PATIENTS WITH CUTANEOUS LEISHMANIASIS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 50(97), 269-274. SID. https://sid.ir/paper/52340/en

Vancouver: Copy

MALEKI MASOUD, JAVIDI Z., TAHERI A.R., EBRAHIMIRAD M., RASTI MASOUD. A STUDY OF HEMATOLOGIC, HEPATIC AND RENAL SIDE EFFECTS OF INTRAMUSCULAR INJECTION OF MEGLUMINE ANTIMONIATE (GLUCANTIME) ON PATIENTS WITH CUTANEOUS LEISHMANIASIS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;50(97):269-274. Available from: https://sid.ir/paper/52340/en

IEEE: Copy

MASOUD MALEKI, Z. JAVIDI, A.R. TAHERI, M. EBRAHIMIRAD, and MASOUD RASTI, “A STUDY OF HEMATOLOGIC, HEPATIC AND RENAL SIDE EFFECTS OF INTRAMUSCULAR INJECTION OF MEGLUMINE ANTIMONIATE (GLUCANTIME) ON PATIENTS WITH CUTANEOUS LEISHMANIASIS,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 50, no. 97, pp. 269–274, 2007, [Online]. Available: https://sid.ir/paper/52340/en

Related Journal Papers