CLINICAL PRESENTATION OF HYPERURICOSURIA IN CHILDREN

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GHANE SHERBAF F.; ESMAEILI MOHAMMAD

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2007 | Volume:50 | Issue:97 Page(s): 291-294

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Title

CLINICAL PRESENTATION OF HYPERURICOSURIA IN CHILDREN

Author(s)

GHANE SHERBAF F. | ESMAEILI MOHAMMAD | Issue Writer Certificate

Keywords

HYPERURICOSURIAQ3

UROLITHIASISQ2

HEMATURIAQ3

DYSURIAQ3

ABDOMINAL PAINQ3

Abstract

Introduction: HYPERURICOSURIA (HU), defined as an increased uric acid excretion, has different symptoms in children and is responsible for the formation of kidney stone. This study was aimed to outline the clinical presentation and natural history of HU in children with HEMATURIA, DYSURIA, discoloration of urine, and recurrent abdominal/flank pain. Material and Methods: In this cross sectional study, from October 2002 to May 2006, 88 children with HYPERURICOSURIA at Dr Sheikh Hospital, Mashhad were evaluated. Urinalysis, urine culture, 24-hour urine collection for measurement of uric acid, Calcium and Creatinine, serum evaluation for BUN, Creatinine, uric acid, Calcium, Phosphorous and HC03- and renal ultrasonugeraphy were carried out done for patients. All data were recorded and analyzed with descriptive statistical methods.Results: From 88 evaluated patients, 51% were boys and 48.8 % were girls. The mean age of children was 5.3±1.2 years. The mean Urine Uric Acid was nA mg/kg/24h and mean Urine PH was 5.3. HEMATURIA was not among the presenting symptoms in 41 patients. Thirty three patients had normal urinalysis at the first examination, 28 of them had microcalculi (<3 mm in diameter) at renal ultrasonography and 12 had stones (4-13 mm). DYSURIA and abdominal/flank pain were present in 22 and 17 patients, respectively. There was no microscopic HEMATURIA in 24.3% of patients with microcalculi or stone. Family history of UROLITHIASIS was positive in 63 of the children.Conclusion: HYPERURICOSURIA has to be suspected in children with DYSURIA, recurrent abdominal / flank pain, discoloration of urine, and familial history of UROLITHIASIS. The lack of HEMATURIA is not predictive of the absence of UROLITHIASIS.

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APA: Copy

GHANE SHERBAF, F., & ESMAEILI, MOHAMMAD. (2007). CLINICAL PRESENTATION OF HYPERURICOSURIA IN CHILDREN. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 50(97), 291-294. SID. https://sid.ir/paper/52341/en

Vancouver: Copy

GHANE SHERBAF F., ESMAEILI MOHAMMAD. CLINICAL PRESENTATION OF HYPERURICOSURIA IN CHILDREN. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;50(97):291-294. Available from: https://sid.ir/paper/52341/en

IEEE: Copy

F. GHANE SHERBAF, and MOHAMMAD ESMAEILI, “CLINICAL PRESENTATION OF HYPERURICOSURIA IN CHILDREN,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 50, no. 97, pp. 291–294, 2007, [Online]. Available: https://sid.ir/paper/52341/en

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