EFFECT OF ALCOHOLIC EXTRACT OF PHOENIX DACTYLIFERA SPATHE ON HISTOLOGICAL CHANGE IN TESTIS AND CONCENTRATIONS OF LH, FSH AND TESTOSTERONE IN MALE RAT

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MOKHTARI M.; SHARIFI E.; MOGHADAMNIA D.

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Journal: Iranian Journal of Basic Medical Sciences Year:2007 | Volume:9 | Issue:4 (32) Page(s): 265-271

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Title

EFFECT OF ALCOHOLIC EXTRACT OF PHOENIX DACTYLIFERA SPATHE ON HISTOLOGICAL CHANGE IN TESTIS AND CONCENTRATIONS OF LH, FSH AND TESTOSTERONE IN MALE RAT

Author(s)

MOKHTARI M. | SHARIFI E. | MOGHADAMNIA D. | Issue Writer Certificate

Keywords

GONADOTROPHSQ2

LUTEINIZING HORMONEQ2

FOLLICLE STIMULATING HORMONEQ2

TESTOSTERONEQ2

RATSQ2

Abstract

ObjectiveThe chemical composition of phoenix dactylifera spathe includes proteins, fibers, moisture, reducing sugar, none-reducing sgar, three kind of cumarin, organic compounds of camphor family, phytosterols and 1, 2-Dimethoxyl 4 methyl benzene. These chemical compounds have biological effects of the antimitotic, estrogenic, anticancer, antidiabetic, antiobesity and antimutation. In the present research, effect of extract of phoenix dactylifera spathe on spermatogenesis, and concentrations of LH, FSH and TESTOSTERONE and histological changes in testis were studied.Materials and MethodsExperiments were done on 50 male wistar RATS weighing 280±10 g. RATS were divided into five groups (n=10) including: the control group receiving nothing, the sham group in which an equal volume of water was injected, the experimental groups receiving 0.05,.0.1,0.2 (g/kg) extract of phoenix dactylifera spathe. Injections were performed intraperitoneally for 14 days. The blood sample were taken 8 hours after receiving last dose at 14th day and the concentrations of lutein hormone (LH), follico stimulating hormone (FSH) and TESTOSTERONE were measured by RIA method. The results were evaluated, using SPSS and Tukey test. In addition at the 14thday the testis was separated and histological changes were studied among experimental, control and sham groups.ResultsStatistical analysis of the results indicated that concentration of TESTOSTERONE showed a significant decrease to different dosage of extract 0.5, 0.1 (g/kg) in comparison to the control and sham groups. In addition histological studies showed a significant effect caused by extract of phoenix dactylifera spathe such as decreased density of spermatozoa in seminiferous tubules and disorders in spermatogenesis. So body weight and testis showed significant decrease in experimental groups in comparison to control and sham groups. Serum levels of LH and FSH didn't show a significant difference in experimental groups compared to control and sham groups.ConclusionAccording to the results alcoholic extract of phoenix dactylifera spathe reduces body weight. This effect is probably due to the presence of phytosterols which decreases total cholesterol, LDL cholesterol and triglycireds and also due to the presence of fiber which decreases blood cholesterol levels and impair to lateral parts of hypothalamus. Also extract reduces testicular weight. This effect is probably due to the presence of phytosterols and cumarin which have antiandrogenic effects which decrease serum levels of TESTOSTERONE and proteins synthesis. In addition, extract reduces tissue sensitivity to androgens and androgens activity. These effects are probably due to the presence of phytosterols which inhibit 5-areductase and aromatase enzymes activity. Also extract reduces concentration of sperm cells in seminiferous tubules. This effect could be due to the presense of phytosterols and cumarin which have estrogenic effects.

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APA: Copy

MOKHTARI, M., SHARIFI, E., & MOGHADAMNIA, D.. (2007). EFFECT OF ALCOHOLIC EXTRACT OF PHOENIX DACTYLIFERA SPATHE ON HISTOLOGICAL CHANGE IN TESTIS AND CONCENTRATIONS OF LH, FSH AND TESTOSTERONE IN MALE RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 9(4 (32)), 265-271. SID. https://sid.ir/paper/52389/en

Vancouver: Copy

MOKHTARI M., SHARIFI E., MOGHADAMNIA D.. EFFECT OF ALCOHOLIC EXTRACT OF PHOENIX DACTYLIFERA SPATHE ON HISTOLOGICAL CHANGE IN TESTIS AND CONCENTRATIONS OF LH, FSH AND TESTOSTERONE IN MALE RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2007;9(4 (32)):265-271. Available from: https://sid.ir/paper/52389/en

IEEE: Copy

M. MOKHTARI, E. SHARIFI, and D. MOGHADAMNIA, “EFFECT OF ALCOHOLIC EXTRACT OF PHOENIX DACTYLIFERA SPATHE ON HISTOLOGICAL CHANGE IN TESTIS AND CONCENTRATIONS OF LH, FSH AND TESTOSTERONE IN MALE RAT,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 9, no. 4 (32), pp. 265–271, 2007, [Online]. Available: https://sid.ir/paper/52389/en

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