THE EFFECTS OF HYPOTHYROIDISM ON CONCENTRATION OF MINERAL ELEMENTS IN SKULL BONE, SKIN AND BRAIN IN RAT

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HADJZADEH M.; RAHIGHI J.; AGHAIE A.

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Journal: Iranian Journal of Basic Medical Sciences Year:2007 | Volume:9 | Issue:4 (32) Page(s): 237-243

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Title

THE EFFECTS OF HYPOTHYROIDISM ON CONCENTRATION OF MINERAL ELEMENTS IN SKULL BONE, SKIN AND BRAIN IN RAT

Author(s)

HADJZADEH M. | RAHIGHI J. | AGHAIE A. | Issue Writer Certificate

Keywords

HYPOTHYROIDISMQ2

MINERALSQ3

CALCIUMQ3

PHOSPHORUSQ3

SULFURQ3

RATSQ3

Abstract

ObjectiveSeveral studies have reported that thyroid dysfunction can induce disturbances in element content in different tissues, both in experimental and human studies. MINERALS have essential role in multifarious function of organs; and disturbances in their content in different tissues can induce several disturbances in affected organs, which produce clinical symptoms and signs. The aim of the present study was to investigate the impacts of HYPOTHYROIDISM on certain mineral concentration in rat tissues.Materials and MethodsIn this study 24 Wistar-Albino RATS aged 2-3 months with 190 - 270 g B.W. were randomly divided into case and control groups. Animals in the case group were received methimazol powder (0.03%) in drinking water. After 4 weeks a sample of blood was taken from all animals for TT4 to determine that if RATS in case group were hypothyroid; then animals were treated for another 3 weeks. At the end of the experiment (day52) all the animals were killed and tissues were removed and kept at -20°C until element concentration were measured. The content of different elements was determined in skull bone, skin and three different regions in brain [cerebral cortex (C.C.), medulla & midbrain (M.M.) and paleocortex (PC)] by Proton Induced X-ray Emission (PIXE) method. SULFUR, Cl, K, Ca, Fe, Cu, Zn and P were determined as PPM for all tissues; the results were represented as Mean±SD and compared between hypothyroid and control groups by unpaired T- test. The differences were considered to be significant when p<0.05. ResultsThe results are as follows: A) Skull bone: in control group the content of CALCIUM was 11646±47188 (ppm) which in experimental group was significantly increased to 172401±27856 (p<0.03). B) Skin: in control group the content of S was 16854±3961 (ppm) which in case group significantly increased to 20738±3739 (p=0.033). C) Brain: in Cerebral Cortex (C.C.): S, Cl, Cu, P, Fe, Ca and K were increased in experimental group (p>0.05), although insignificant.In Medulla and Midbrain (M.M.): in control group the content of P was 17447±5889 (PPM) which significantly increased to 23189±4115 in case group (p<0.03).In paleocortex (PC): Cl, K, Ca and Zn were increased, and Cu was decreased in experimental group, although insignificant.ConclusionThese data demonstrated that HYPOTHYROIDISM can change the content of several elements in the examined tissues and these variations may be involved in part in several clinical manifestations which are present in HYPOTHYROIDISM.

Cites

THE PREVALANCE OF HYPERCHOLESTEROLEMIA IN MIDDLE-AGED AND ELDERLY POPULATION IN MASHHAD AND ITS RELATION TO HYPOTHYROIDISM

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APA: Copy

HADJZADEH, M., RAHIGHI, J., & AGHAIE, A.. (2007). THE EFFECTS OF HYPOTHYROIDISM ON CONCENTRATION OF MINERAL ELEMENTS IN SKULL BONE, SKIN AND BRAIN IN RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 9(4 (32)), 237-243. SID. https://sid.ir/paper/52393/en

Vancouver: Copy

HADJZADEH M., RAHIGHI J., AGHAIE A.. THE EFFECTS OF HYPOTHYROIDISM ON CONCENTRATION OF MINERAL ELEMENTS IN SKULL BONE, SKIN AND BRAIN IN RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2007;9(4 (32)):237-243. Available from: https://sid.ir/paper/52393/en

IEEE: Copy

M. HADJZADEH, J. RAHIGHI, and A. AGHAIE, “THE EFFECTS OF HYPOTHYROIDISM ON CONCENTRATION OF MINERAL ELEMENTS IN SKULL BONE, SKIN AND BRAIN IN RAT,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 9, no. 4 (32), pp. 237–243, 2007, [Online]. Available: https://sid.ir/paper/52393/en

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