DETERMINING THE DOSE AND TIME OF VINBLASTIN TREATMENT FOR INDUCTION OF ANEUPLOIDY IN MOUSE (BALB/C) BONE MARROW CELLS USING MICRONUCLEUS ASSAY

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MALVANDI A.M.; HADAD F.; MOGHIMI A.

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Journal: Iranian Journal of Basic Medical Sciences Year:2007 | Volume:10 | Issue:1 (33) Page(s): 46-53

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Information Journal Paper

Title

DETERMINING THE DOSE AND TIME OF VINBLASTIN TREATMENT FOR INDUCTION OF ANEUPLOIDY IN MOUSE (BALB/C) BONE MARROW CELLS USING MICRONUCLEUS ASSAY

Author(s)

MALVANDI A.M. | HADAD F. | MOGHIMI A. | Issue Writer Certificate

Keywords

ANEUPLOIDYQ3

VINBLASTINQ3

MICRONUCLEUSQ3

Abstract

ObjectiveANEUPLOIDY is believed to be the main reason for cancer incidence in human populations. VINBLASTIN is being used as a mitotic block for treatment of some types of cancer. At the same time VINBLASTIN is being counted as an alkaloid member of Vinca family which all of those are believed to be non-mutagenic carcinogens. Due to its dual nature, analyzing the effect of vinblast in and the relationship of ANEUPLOIDY and cancer is very active line of work in biological studies.Materials and Methods In this study to evaluate the doses and time course of VINBLASTIN treatment for induction of ANEUPLOIDY in mouse bone marrow cells, using MICRONUCLEUS assay, frequency of MICRONUCLEUS was calculated in doses of 1, 2, 3, and5 mg/kg of body weight at 6, 18, 24, and 30 hours post treatment.ResultsData revealed that 2 mg/kg of bodyweight of vinblast in could induce a high frequency of ANEUPLOIDY, estimated by high frequency of MICRONUCLEUS, at 24 hours post-treatment. All the dose and time- interval used in this experiment, the frequency of induced- MICRONUCLEUS was increased up to 5 to control.ConclusionOn the basis of this study we introduce an in vivo model for studying the relationship between ANEUPLOIDY and cancer and also in cancer therapy.

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APA: Copy

MALVANDI, A.M., HADAD, F., & MOGHIMI, A.. (2007). DETERMINING THE DOSE AND TIME OF VINBLASTIN TREATMENT FOR INDUCTION OF ANEUPLOIDY IN MOUSE (BALB/C) BONE MARROW CELLS USING MICRONUCLEUS ASSAY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 10(1 (33)), 46-53. SID. https://sid.ir/paper/52424/en

Vancouver: Copy

MALVANDI A.M., HADAD F., MOGHIMI A.. DETERMINING THE DOSE AND TIME OF VINBLASTIN TREATMENT FOR INDUCTION OF ANEUPLOIDY IN MOUSE (BALB/C) BONE MARROW CELLS USING MICRONUCLEUS ASSAY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2007;10(1 (33)):46-53. Available from: https://sid.ir/paper/52424/en

IEEE: Copy

A.M. MALVANDI, F. HADAD, and A. MOGHIMI, “DETERMINING THE DOSE AND TIME OF VINBLASTIN TREATMENT FOR INDUCTION OF ANEUPLOIDY IN MOUSE (BALB/C) BONE MARROW CELLS USING MICRONUCLEUS ASSAY,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 10, no. 1 (33), pp. 46–53, 2007, [Online]. Available: https://sid.ir/paper/52424/en

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