DETECTION OF HHV-8 AND HTLV-1 SEQUENCES IN KAPOSI'S SARCOMA

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MAHMOUDI M.; RASTIN M.; KHOUEI A.R.

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Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2005 | Volume:8 | Issue:2 (26) Page(s): 119-124

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Information Journal Paper

Title

DETECTION OF HHV-8 AND HTLV-1 SEQUENCES IN KAPOSI'S SARCOMA

Author(s)

MAHMOUDI M. | RASTIN M. | KHOUEI A.R. | Issue Writer Certificate

Keywords

KAPOSI'S SARCOMAQ4

HHV-8Q3

HTLV-1Q4

Abstract

Objective: KAPOSI'S SARCOMA (KS) is a common malignant tumor in immuno compromised individuals and in organ transplant recipients due to immunosuppressive drugs. The correlation of lymphotropic viruses such as HHV-8 and HTLV-l to KS is currently being studied. These viruses may be the risk factors or the primary cause of KS. The presence of HHV-8 and HTLV-1 genome was determined in archived skin biopsies diagnosed as KS. Material and Method: In this study we selected 35 paraffin embedded skin biopsies with KS diagnosis. These diagnoses were reconfirmed by careful microscopic examination. Five micron thick sections of the blocks were prepared; and after deparaffmization, their DNA was extracted. Using LTR, tax and pol specific primers and ORF-26 and ORFK 9-1 specific primers the HTLV-1 and the HHV-8 genomes were amplified; respectively. Results: Our results indicate that none of the KS tissues were infected with HTLV-1, however we detected the presence of HHV-8 genome in all of the specimens. Conclusion: According to these findings, it seems that HTLV-1 infection does not affect the process of HHV-8 activation.

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APA: Copy

MAHMOUDI, M., RASTIN, M., & KHOUEI, A.R.. (2005). DETECTION OF HHV-8 AND HTLV-1 SEQUENCES IN KAPOSI'S SARCOMA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 8(2 (26)), 119-124. SID. https://sid.ir/paper/52434/en

Vancouver: Copy

MAHMOUDI M., RASTIN M., KHOUEI A.R.. DETECTION OF HHV-8 AND HTLV-1 SEQUENCES IN KAPOSI'S SARCOMA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2005;8(2 (26)):119-124. Available from: https://sid.ir/paper/52434/en

IEEE: Copy

M. MAHMOUDI, M. RASTIN, and A.R. KHOUEI, “DETECTION OF HHV-8 AND HTLV-1 SEQUENCES IN KAPOSI'S SARCOMA,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 8, no. 2 (26), pp. 119–124, 2005, [Online]. Available: https://sid.ir/paper/52434/en

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