INVESTIGATION ON ANALGESICS & ANTIIFLAMMATORY EFFECTS OF ROSA DAMASCENA
EXTRACT ON MOUSE AND RAT

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RAKHAHANDEH H.; DOULATI K.; HOSEINI M.; ESMAEILZADEH M.

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Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2004 | Volume:7 | Issue:3 (23) Page(s): 151-156

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Title

INVESTIGATION ON ANALGESICS & ANTIIFLAMMATORY EFFECTS OF ROSA DAMASCENA EXTRACT ON MOUSE AND RAT

Author(s)

RAKHAHANDEH H. | DOULATI K. | HOSEINI M. | ESMAEILZADEH M. | Issue Writer Certificate

Keywords

ROSA DAMASCENAQ3

PAINQ2

INFLAMMATIONQ2

TAIL FLICKQ3

HOT PLATEQ3

Abstract

ROSA DAMASCENA is well known in herbal medicine. In addition to perfume effect, in traditional medicine several pharmacological effects of this plant such as beneficial effects for premenstrual breast tenderness, anti-inflammatory, treatment of abdominal and chest PAIN were reported. In the present study, the analgesic and anti-inflammatory effects of 100, 500 and 1000 mg/kg aqueous, ethanolic and chloroformic suxheleted extracts of ROSA DAMASCENA were investigated. Analgesic effect of extracts was measured by HOT PLATE and TAIL FLICK methods and INFLAMMATION was produced in the rats using carrageenan sodium salt. Anti-inflammatory effect was investigated through measurement of foot volume by displacement technique using a calibrated glass tube. The results showed that ethanolic extract had significant analgesic and anti-inflammatory effects comparable to morphine and diclofenac sodium respectively. Pretreatment of animals with naloxan significantly reduced analgesic effect of extract. Therefore the analgesic effect of extract seems to be, at least in part, through the opioid system.

Cites

EXTRACTION AND SEPARATION OF SEDATIVE COMPOUNDS FROM PETALS OF ROSA DAMASCENA MILL.

References

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APA: Copy

RAKHAHANDEH, H., DOULATI, K., HOSEINI, M., & ESMAEILZADEH, M.. (2004). INVESTIGATION ON ANALGESICS & ANTIIFLAMMATORY EFFECTS OF ROSA DAMASCENA EXTRACT ON MOUSE AND RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 7(3 (23)), 151-156. SID. https://sid.ir/paper/52449/en

Vancouver: Copy

RAKHAHANDEH H., DOULATI K., HOSEINI M., ESMAEILZADEH M.. INVESTIGATION ON ANALGESICS & ANTIIFLAMMATORY EFFECTS OF ROSA DAMASCENA EXTRACT ON MOUSE AND RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2004;7(3 (23)):151-156. Available from: https://sid.ir/paper/52449/en

IEEE: Copy

H. RAKHAHANDEH, K. DOULATI, M. HOSEINI, and M. ESMAEILZADEH, “INVESTIGATION ON ANALGESICS & ANTIIFLAMMATORY EFFECTS OF ROSA DAMASCENA EXTRACT ON MOUSE AND RAT,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 7, no. 3 (23), pp. 151–156, 2004, [Online]. Available: https://sid.ir/paper/52449/en

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