INVESTIGATION OF THE EFFECTS OF POLYSORBATE NON-IONIC SURFACTANTS ON BIOLOGICAL
MEMBRANES USING HUMAN ERYTHROCYTES AS A MODEL

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SAJADI TABASSI S.A.; NANIROUDI M.A.

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Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2004 | Volume:7 | Issue:3 (23) Page(s): 157-162

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Title

INVESTIGATION OF THE EFFECTS OF POLYSORBATE NON-IONIC SURFACTANTS ON BIOLOGICAL MEMBRANES USING HUMAN ERYTHROCYTES AS A MODEL

Author(s)

SAJADI TABASSI S.A. | NANIROUDI M.A. | Issue Writer Certificate

Keywords

MEMBRANEQ3

HEMOLYSISQ3

NON-IONIC SURFACTANTQ4

POLYSORBATEQ3

Abstract

Surfactants are widely used as detergents, emulsifiers, solubilizers and in recent years as penetration enhancers. In the present study, the hemolytic effects of four NON-IONIC SURFACTANTs from the POLYSORBATE (Tween®) series including Tween®20, 40, 60 and 80 were investigated on human red blood cells as an indication of their MEMBRANE disrupting potentials. The results showed that all four surfactants were hemolytic to different extents such that the maximum HEMOLYSIS occurred at 1.6,40, 80 and 80 mM by Tween®20, 40, 60 and 80 respectively. This indicates that Tween®20 is much more damaging to biological MEMBRANEs than the other three surfactants. The effect of temperature on HEMOLYSIS induced by surfactants was also examined, and it was found that an increase in temperature from 25 to 37°C resulted in a significant increase in HEMOLYSIS. When 2 mM Tween® 80 was added to the solution of Tween®20 the HEMOLYSIS reduced from 75% to about 1% which shows a mitigating effect for Tween ® 80 on the HEMOLYSIS caused by Tween® 20.

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APA: Copy

SAJADI TABASSI, S.A., & NANIROUDI, M.A.. (2004). INVESTIGATION OF THE EFFECTS OF POLYSORBATE NON-IONIC SURFACTANTS ON BIOLOGICAL MEMBRANES USING HUMAN ERYTHROCYTES AS A MODEL. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 7(3 (23)), 157-162. SID. https://sid.ir/paper/52450/en

Vancouver: Copy

SAJADI TABASSI S.A., NANIROUDI M.A.. INVESTIGATION OF THE EFFECTS OF POLYSORBATE NON-IONIC SURFACTANTS ON BIOLOGICAL MEMBRANES USING HUMAN ERYTHROCYTES AS A MODEL. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2004;7(3 (23)):157-162. Available from: https://sid.ir/paper/52450/en

IEEE: Copy

S.A. SAJADI TABASSI, and M.A. NANIROUDI, “INVESTIGATION OF THE EFFECTS OF POLYSORBATE NON-IONIC SURFACTANTS ON BIOLOGICAL MEMBRANES USING HUMAN ERYTHROCYTES AS A MODEL,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 7, no. 3 (23), pp. 157–162, 2004, [Online]. Available: https://sid.ir/paper/52450/en

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