MICROVESSEL DENSITY IN DUCTAL CARCINOMA OF BREAST AND COMPARISON WITH NORMAL BREAST TISSUE

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SADEGHIAN M.H.; SHARIFI N.; SHAKERI M.T.

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Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2005 | Volume:8 | Issue:4 (28) Page(s): 246-251

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Information Journal Paper

Title

MICROVESSEL DENSITY IN DUCTAL CARCINOMA OF BREAST AND COMPARISON WITH NORMAL BREAST TISSUE

Author(s)

SADEGHIAN M.H. | SHARIFI N. | SHAKERI M.T. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

MICROVASCULAR DENSITY (MVD)Q4

IMMUNOHISTOCHEMISTRYQ3

ANGIOGENESISQ3

Abstract

Objective: Carcinoma of the breast is the most common malignancy in adult women, and attention to it often overshadows that given other breast lesions. ANGIOGENESIS is essential for BREAST CANCER progression and high microvessel density (MVD) within a primary tumor has been associated with stronger likelihood of nodal metastasis and poor prognosis.Materials and Methods: In this study 50 cases of invasive ductal carcinoma of the breast were selected that had been diagnosed and archived in the Pathology Department of Mashhad Ghaem Hospital. Paraffin blocks, were cut and stained for CD34 immunohistochemical marker. Immunohistochemical slides were evaluated for microvascular density in hot spot within the tumoral and normal paratumoral tissue. Correlation between MVD with other parameters such as, age, histologic grade, lymph node involvement and tumoral sizes analyzed by parametric and nonparametric statistical evidence.Results: MVD in normal tissue was adjusted to the tumor, and the ductal carcinoma had significant difference (12.42±2.5 and 46.76±23.4 respectivly).MVD had relative correlation with increased histologic grade (42.3±25.1 for grade I and 63.75±36.5 for grade III).Conclusion: Results of this study shows markedly differences between MVD in normal and tumoral breast tissue, also increase of histological grade have correlation with MVD increment.

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APA: Copy

SADEGHIAN, M.H., SHARIFI, N., & SHAKERI, M.T.. (2005). MICROVESSEL DENSITY IN DUCTAL CARCINOMA OF BREAST AND COMPARISON WITH NORMAL BREAST TISSUE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 8(4 (28)), 246-251. SID. https://sid.ir/paper/52465/en

Vancouver: Copy

SADEGHIAN M.H., SHARIFI N., SHAKERI M.T.. MICROVESSEL DENSITY IN DUCTAL CARCINOMA OF BREAST AND COMPARISON WITH NORMAL BREAST TISSUE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2005;8(4 (28)):246-251. Available from: https://sid.ir/paper/52465/en

IEEE: Copy

M.H. SADEGHIAN, N. SHARIFI, and M.T. SHAKERI, “MICROVESSEL DENSITY IN DUCTAL CARCINOMA OF BREAST AND COMPARISON WITH NORMAL BREAST TISSUE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 8, no. 4 (28), pp. 246–251, 2005, [Online]. Available: https://sid.ir/paper/52465/en

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