EFFECT OF ANETHUM GRAVEOLENS FRUIT EXTRACT ON RAT UTERUS CONTRACTIONS

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GHARIBN ASERI M.K.; MARD S.A.; FARBOUD Y.

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Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2005 | Volume:8 | Issue:4 (28) Page(s): 263-270

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Information Journal Paper

Title

EFFECT OF ANETHUM GRAVEOLENS FRUIT EXTRACT ON RAT UTERUS CONTRACTIONS

Author(s)

GHARIBN ASERI M.K. | MARD S.A. | FARBOUD Y. | Issue Writer Certificate

Keywords

DILL FRUITQ4

RATQ3

UTERUSQ2

KC1Q3

OXYTOCINQ3

Abstract

Objective: Dill (Anethum graveolens) from Umbelliferae is used traditionally to treat convulsions and increasing milk production. Also, in Darab (Fars Province) and Yazd DILL FRUIT is used traditionally to prevent abortion. Its antimicrobial, antihyperlipidaemic, anti-hypercholesteroaemic effects and reducing gastric acid secretion have been reported. The aim of the present study was to investigate the effects of DILL FRUIT hydroalcoholic (DFHE) extract on virgin RAT UTERUS contractions induced by KCI (60mM) and OXYTOCIN (10mU/ml).Materials and Methods: Macerated method was used for extract preparation. Virgin Sprague Dawley female RATs were pretreated with an injection of estradiol valerate (5mg/kg, s.c.) 24 hours prior to experiment. RATs were killed and uteri were dissected and mounted in an isolated organ bath containing De Jalon solutions (29°C) bubbled by oxygen. Contractile responses were recorded isometrically under 1g initial tension.Results: The DFHE (0.5, 1, 2, 4 and 8mglml) relaxed both KC1- and OXYTOCIN-induced contractions dosedependently (p<0.0001). However, the spasmolytic effect of extract on OXYTOCIN-induced contractions was more potent. In Ca2+-free, rich K+ (120mM) De Jalon solution, cumulative adding of calcium (0.15, 0.3, 0.6, 1.2 and 2.4 mM), increased contractions dose dependently (p<0.0001). DFHE (4 mg/ml) shifted this dose-response curve to the right (p<0.05). In Ca2+ free solution, OXYTOCIN induced strong contractions if calcium (0.3 mM) was added to the bath. However, DFHE (8 mg/ml) reduced calcium-induced contraction (p<0.001). The spasmolytic effect of DFHE was reversible. The spasmolytic effect of DFHE (4 mg/ml) was affected neither by propranolol (1µM) nor by L-NAME (100µM).Conclusion: These results suggest that the relaxatory effect of DFHE on KCI and OXYTOCIN-induced UTERUS contractions is due, at least in part, to blockade voltage dependent calcium channels and partly by disturbing in releasing calcium from intracellular pool indirectly. In addition, the β-adrenoceptors and NO are not involved in this inhibitory effect of DFHE. Our results may also support the traditionally usage of DILL FRUIT for preventing abortion.

Cites

SPASMOLYTIC EFFECT OF ANETHUM GRAVEOLENS (DILL) FRUIT EXTRACT ON RAT ILEUM

References

بررسی تاثیر عصاره تخم شوید خوراکی بر خونریزی پس از زایمان طبیعی

Cite

APA: Copy

GHARIBN ASERI, M.K., MARD, S.A., & FARBOUD, Y.. (2005). EFFECT OF ANETHUM GRAVEOLENS FRUIT EXTRACT ON RAT UTERUS CONTRACTIONS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 8(4 (28)), 263-270. SID. https://sid.ir/paper/52469/en

Vancouver: Copy

GHARIBN ASERI M.K., MARD S.A., FARBOUD Y.. EFFECT OF ANETHUM GRAVEOLENS FRUIT EXTRACT ON RAT UTERUS CONTRACTIONS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2005;8(4 (28)):263-270. Available from: https://sid.ir/paper/52469/en

IEEE: Copy

M.K. GHARIBN ASERI, S.A. MARD, and Y. FARBOUD, “EFFECT OF ANETHUM GRAVEOLENS FRUIT EXTRACT ON RAT UTERUS CONTRACTIONS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 8, no. 4 (28), pp. 263–270, 2005, [Online]. Available: https://sid.ir/paper/52469/en

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