EFFECT OF CARBENOXOLONE ON LIPID PEROXIDATION LEVEL DURING GLOBAL ISCHEMIC-REPERFUSION IN HIPPOCAMPAL RAT SLICES

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NASIRIASL M.; PARVARDEH S.; HOSSEINZADEH H.

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Journal: Iranian Journal of Basic Medical Sciences Year:2004 | Volume:6 | Issue:4 (20) Page(s): 289-293

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Information Journal Paper

Title

EFFECT OF CARBENOXOLONE ON LIPID PEROXIDATION LEVEL DURING GLOBAL ISCHEMIC-REPERFUSION IN HIPPOCAMPAL RAT SLICES

Author(s)

NASIRIASL M. | PARVARDEH S. | HOSSEINZADEH H. | Issue Writer Certificate

Keywords

CARBENOXOLONEQ4

GAPJUNCTIONSQ4

MDAQ4

CEREBRAL ISCHEMIC-REPERFUSIONQ4

Abstract

Present studies have shown that gap junction channels could be a novel target to reduce brain damage during cerebral ischemia. CARBENOXOLONE, a gap junction channel blocker decreased the spread of cell death in in vitro brain ischemic model and inhibition of lipid peroxidation has been of much interest to ameliorate excitotoxic neuronal damage. Thus the aim of the present study was to determine the effect of CARBENOXOLONE on lipid peroxidation in experimental global ischemic-reperfusion in the rat hippocampus. The brain damages were determined using the measurement malondialdehyde (MDA). Cerebral ischemia was induced by four-vessel-occlusion (4VO). CARBENOXOLONE (50-200mg/kg), phenytoin (50 mg/kg) and normal saline (10ml/kg) were administered intraperitoneally immediately after reperfusion. The malondialdehyde (MDA) was measured using the thiobarbituric acid (TBA) test. The MDA level was higher in the saline group during ischemic-reperfusion than the sham group. The MDA levels recovered significantly upon phenytoin and CARBENOXOLONE (100-200 mg/kg) therapy in the ischemic-reperfusion. These results suggest that CARBENOXOLONE may protect the brain against lipid peroxidation in cerebral ischemia.

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APA: Copy

NASIRIASL, M., PARVARDEH, S., & HOSSEINZADEH, H.. (2004). EFFECT OF CARBENOXOLONE ON LIPID PEROXIDATION LEVEL DURING GLOBAL ISCHEMIC-REPERFUSION IN HIPPOCAMPAL RAT SLICES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 6(4 (20)), 289-293. SID. https://sid.ir/paper/52475/en

Vancouver: Copy

NASIRIASL M., PARVARDEH S., HOSSEINZADEH H.. EFFECT OF CARBENOXOLONE ON LIPID PEROXIDATION LEVEL DURING GLOBAL ISCHEMIC-REPERFUSION IN HIPPOCAMPAL RAT SLICES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2004;6(4 (20)):289-293. Available from: https://sid.ir/paper/52475/en

IEEE: Copy

M. NASIRIASL, S. PARVARDEH, and H. HOSSEINZADEH, “EFFECT OF CARBENOXOLONE ON LIPID PEROXIDATION LEVEL DURING GLOBAL ISCHEMIC-REPERFUSION IN HIPPOCAMPAL RAT SLICES,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 6, no. 4 (20), pp. 289–293, 2004, [Online]. Available: https://sid.ir/paper/52475/en

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