BELICOBACTER PYLORI ATTACHMENT TO 7 MAMALIAN CELL LINES (HEPII, HELA, SW742, AGS, HT29/219, HT29, CACO-2)

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RAHIMIFARD N.; MIRSALEHIAN A.; MALEKNEZHAD P.; EBRAHIMI DARYANI N.

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Journal: Iranian Journal of Basic Medical Sciences Year:2004 | Volume:6 | Issue:4 (20) Page(s): 294-300

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Title

BELICOBACTER PYLORI ATTACHMENT TO 7 MAMALIAN CELL LINES (HEPII, HELA, SW742, AGS, HT29/219, HT29, CACO-2)

Author(s)

RAHIMIFARD N. | MIRSALEHIAN A. | MALEKNEZHAD P. | EBRAHIMI DARYANI N. | Issue Writer Certificate

Keywords

HELICOBACTER PYLORIQ3

ATTACHMENTQ3

CELL CULTUREQ2

Abstract

HELICOBACTER PYLORI is the etiologic agent of chronic-active gastritis, gastroduodenal ulcers in humans, and a co-factor in the occurrence of gastric cancer and mucosa-associated lymphoid tumors. Adherence of H. pylori to the gastric mucosa is a critical, initial step in the pathogenesis of the disease. So bacterial adhesion inhibitory agents provide a novel pharmacologic approach to the management of infectious diseases. 22 H. pylori strains, obtained from the antral or duodenal biopsies of 49 patients with dyspepsia, gastritis, gastric ulcer, duodenal ulcer, etc. were assayed by ELISA reader (UPR: Urea Phenol Red) to investigate the diversity of ATTACHMENT to 7 mamalian cell lines. The concentration of H. pylori and cell suspension, the condition and temperature, can alter the ATTACHMENT rate. H. pylori can attach to all 7 cell lines. There are no significant differences between 22 H. pylori strains in ATTACHMENT to cells. The ATTACHMENT pattern of H. pylori to the cells showed significant reduction respectively from HepII, HeLa, SW742, AGS, HT29/219, HT29 to Caco-2. Best ATTACHMENT was seen to HepII, HeLa and SW742 cells, and among these HepII were the best cells for this purpose. Our studies suggest that HepII, HeLa and SW742 cells could serve as a suitable in-vitro model for the study of H. pylori adhesions, ATTACHMENT, inhibition of ATTACHMENT and detachment assays and among these HepII cell is preferably recommended.

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APA: Copy

RAHIMIFARD, N., MIRSALEHIAN, A., MALEKNEZHAD, P., & EBRAHIMI DARYANI, N.. (2004). BELICOBACTER PYLORI ATTACHMENT TO 7 MAMALIAN CELL LINES (HEPII, HELA, SW742, AGS, HT29/219, HT29, CACO-2). IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 6(4 (20)), 294-300. SID. https://sid.ir/paper/52476/en

Vancouver: Copy

RAHIMIFARD N., MIRSALEHIAN A., MALEKNEZHAD P., EBRAHIMI DARYANI N.. BELICOBACTER PYLORI ATTACHMENT TO 7 MAMALIAN CELL LINES (HEPII, HELA, SW742, AGS, HT29/219, HT29, CACO-2). IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2004;6(4 (20)):294-300. Available from: https://sid.ir/paper/52476/en

IEEE: Copy

N. RAHIMIFARD, A. MIRSALEHIAN, P. MALEKNEZHAD, and N. EBRAHIMI DARYANI, “BELICOBACTER PYLORI ATTACHMENT TO 7 MAMALIAN CELL LINES (HEPII, HELA, SW742, AGS, HT29/219, HT29, CACO-2),” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 6, no. 4 (20), pp. 294–300, 2004, [Online]. Available: https://sid.ir/paper/52476/en

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