THE EFFECT OF TAMOXIFEN ON SERUM THYROID HORMONES AND TSH IN RATS WITH DMBA-INDUCED MAMMARY TUMORS

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KARAMI TEHRANI FATEMEH; MOKARRAM P.; SALAMI S.

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Journal: Iranian Journal of Basic Medical Sciences Year:2000 | Volume:3 | Issue:2 (7) Page(s): 89-93

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Title

THE EFFECT OF TAMOXIFEN ON SERUM THYROID HORMONES AND TSH IN RATS WITH DMBA-INDUCED MAMMARY TUMORS

Author(s)

KARAMI TEHRANI FATEMEH | MOKARRAM P. | SALAMI S. | Issue Writer Certificate

Keywords

THYROID HORMONESQ2

TAMOXIFENQ4

TBG.Q4

Abstract

Tamoxifen is a nonsteroidal antiestrogen which prevents the growth of malignant breast tumors, through blocking estrogen receptors. Anti-estrogenic action of TAMOXIFEN has well established in breast cancer, However it has been shown that it behaves like estrogn in some tissues. The aim of this study is to investigate the estrogenic action of TAMOXIFENon serum TBG. FT3 (Free T3), FT4 (Free T4) and TSH (Thyroid - Stimulating - Hormone). In this investigation, Rats with DMBA-induced mammary tumors were treated with TAMOXIFEN (200 µg / 0.1 ml, one day interval) for 4 weeks and with 0.1 ml saline as controls. The results demonstrated a significant reduction in values observed for serum T3 uptake (p= 0.002), FT3 (p= 0.01), FT4 (p= 0.02) and a significant elevation of serum TSH levels (p= 0.008) in comparison to those observed for controls. In responses to longterm TAMOXIFEN therapy, serum FT3 and FT4 were reduced significantly, more likely due to the increase in the TBG.binding capacity, which in turn, resulted in the elevation of serum TSH levels. In conclusion, a fall in Ff3 and Ff4 associated with increasing in the level of TSH suggest a reduced Bioavailability of those hormones during TAMOXIFEN therapy.

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APA: Copy

KARAMI TEHRANI, FATEMEH, MOKARRAM, P., & SALAMI, S.. (2000). THE EFFECT OF TAMOXIFEN ON SERUM THYROID HORMONES AND TSH IN RATS WITH DMBA-INDUCED MAMMARY TUMORS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 3(2 (7)), 89-93. SID. https://sid.ir/paper/52519/en

Vancouver: Copy

KARAMI TEHRANI FATEMEH, MOKARRAM P., SALAMI S.. THE EFFECT OF TAMOXIFEN ON SERUM THYROID HORMONES AND TSH IN RATS WITH DMBA-INDUCED MAMMARY TUMORS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2000;3(2 (7)):89-93. Available from: https://sid.ir/paper/52519/en

IEEE: Copy

FATEMEH KARAMI TEHRANI, P. MOKARRAM, and S. SALAMI, “THE EFFECT OF TAMOXIFEN ON SERUM THYROID HORMONES AND TSH IN RATS WITH DMBA-INDUCED MAMMARY TUMORS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 3, no. 2 (7), pp. 89–93, 2000, [Online]. Available: https://sid.ir/paper/52519/en

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