COMPARISON OF THERAPEUTIC AND SHORT TERM SIDE EFFECTS OF ANETHUM WITH NICOTINIC ACID, CHOLESTYRAMINE, THE COMBINATION OF THE TWO, AND PLACEBO FOR ISOLATED HYPERCHOLESTEROLEMIA; A DOUBLE BLIND, RANDOMIZED CLINICAL TRIAL

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FOTOUHI A.; ASGHARI F.; MIRZAZADEH AZIM; ALA ALDINI F.; YAZDANI K.; ARIA ARASH; SAFAEI A.; VAFADAR J.

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Journal: Journal of Medicinal Plants Year:2002 | Volume:1 | Issue:3 Page(s): 0-0

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Title

COMPARISON OF THERAPEUTIC AND SHORT TERM SIDE EFFECTS OF ANETHUM WITH NICOTINIC ACID, CHOLESTYRAMINE, THE COMBINATION OF THE TWO, AND PLACEBO FOR ISOLATED HYPERCHOLESTEROLEMIA; A DOUBLE BLIND, RANDOMIZED CLINICAL TRIAL

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Keywords

ANETHUM

HYPERCHOLESTEROLEMIA

NICOTINIC ACID

CHOLESTYRAMINE

CLINICAL TRIAL

Abstract

ANETHUM is a herbal drug production and prescription of which, as a lipid lowering drug, has been approved in Iran. Its widespread use and lack of studies done on it emphasizes on the necessity of a controlled CLINICAL TRIAL. Two hundred and one hypercholesterolemic patients (total cholesterol >240 mg/d) diagnosed on basis of two consecutive lab tests, separated by at least two weeks, comprised the study population. Patients were randomized into the following therapy groups after 2 weeks of diet therapy: 1) CHOLESTYRAMINE 12 g per day, 2) NICOTINIC ACID 3 g per day, 3) CHOLESTYRAMINE 12g per day plus NICOTINIC ACID 3 g per day, 4) ANETHUM 6 tablets per day, 5) Placebo. One hundred and fourteen patients completed the 2 months follow up. A third lab test at the end of the course revealed a 2.0% reduction of cholesterol level in the ANETHUM group. Triglyceride had %3.1 rise in ANETHUM group (not significant). Low density lipoprotein cholesterol (LDL-C) was increased by 6.1% in the ANETHUM group (not significant). The most common side effects of ANETHUM were non specific complaints (i.e. malaise and fatigue). One patient discontinued therapy because of abdominal pain. ANETHUM caused a 2.2 mg/dl rise in blood urea nitrogen (P=0.016) and 0.12 mg/dl rise in creatinine (P=0.019). Based on the results, we conclude that ANETHUM is not significantly different from placebo in its therapeutic effects, moreover there are clinical evidence on its untoward effects by increasing LDL-C. Although this study hasnt proved untoward effects of ANETHUM statistically but showes lack of any beneficial effects.

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APA: Copy

FOTOUHI, A., ASGHARI, F., MIRZAZADEH, AZIM, ALA ALDINI, F., YAZDANI, K., ARIA, ARASH, SAFAEI, A., & VAFADAR, J.. (2002). COMPARISON OF THERAPEUTIC AND SHORT TERM SIDE EFFECTS OF ANETHUM WITH NICOTINIC ACID, CHOLESTYRAMINE, THE COMBINATION OF THE TWO, AND PLACEBO FOR ISOLATED HYPERCHOLESTEROLEMIA; A DOUBLE BLIND, RANDOMIZED CLINICAL TRIAL. JOURNAL OF MEDICINAL PLANTS, 1(3), 0-0. SID. https://sid.ir/paper/527696/en

Vancouver: Copy

FOTOUHI A., ASGHARI F., MIRZAZADEH AZIM, ALA ALDINI F., YAZDANI K., ARIA ARASH, SAFAEI A., VAFADAR J.. COMPARISON OF THERAPEUTIC AND SHORT TERM SIDE EFFECTS OF ANETHUM WITH NICOTINIC ACID, CHOLESTYRAMINE, THE COMBINATION OF THE TWO, AND PLACEBO FOR ISOLATED HYPERCHOLESTEROLEMIA; A DOUBLE BLIND, RANDOMIZED CLINICAL TRIAL. JOURNAL OF MEDICINAL PLANTS[Internet]. 2002;1(3):0-0. Available from: https://sid.ir/paper/527696/en

IEEE: Copy

A. FOTOUHI, F. ASGHARI, AZIM MIRZAZADEH, F. ALA ALDINI, K. YAZDANI, ARASH ARIA, A. SAFAEI, and J. VAFADAR, “COMPARISON OF THERAPEUTIC AND SHORT TERM SIDE EFFECTS OF ANETHUM WITH NICOTINIC ACID, CHOLESTYRAMINE, THE COMBINATION OF THE TWO, AND PLACEBO FOR ISOLATED HYPERCHOLESTEROLEMIA; A DOUBLE BLIND, RANDOMIZED CLINICAL TRIAL,” JOURNAL OF MEDICINAL PLANTS, vol. 1, no. 3, pp. 0–0, 2002, [Online]. Available: https://sid.ir/paper/527696/en

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