COMPARING THE EFFICACY OF FURAZOLIDONE-CONTAINING AND BISMUTH-CONTAINING DRUGS IN ERADICATION OF HELICOBACTER PYLORI IN PATIENTS WITH DUODENAL ULCER

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HOMAYOUNI MOHAMMAD; ZOJAJI H.; MEHRABIAN A.A.; AHMADZADEH A.

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Journal: Researcher Bulletin of Medical Sciences Year:2001 | Volume:6 | Issue:1 (21) Page(s): 57-62

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Title

COMPARING THE EFFICACY OF FURAZOLIDONE-CONTAINING AND BISMUTH-CONTAINING DRUGS IN ERADICATION OF HELICOBACTER PYLORI IN PATIENTS WITH DUODENAL ULCER

Author(s)

HOMAYOUNI MOHAMMAD | ZOJAJI H. | MEHRABIAN A.A. | AHMADZADEH A. | Issue Writer Certificate

Keywords

DUODENAL ULCER

HELICOBACTER PYLORI

BISMUTH

FURAZOLIDONE

Abstract

Background: Regarding the strong relationship between DUODENAL ULCER and HELICOBACTER PYLORI infection, eradication of this organism seems to be inevitable to maintain complete treatment. A combined regimen of BISMUTH, amoxicillin and metronidazole is the most commonly used therapeutic regimen. With respect to the reports of successful usage of FURAZOLIDONE-containing drugs and also its lower price, this study has been carried out to compare the efficacy of FURAZOLIDONE-containing and BISMUTH-containing drugs in patients with DUODENAL ULCER referring to Shohada-e- Tjrish hospital since January 1997 till June 1998. Materials and methods: This clinical trial had performed on 151 patients, 83 men and 68 women. After documenting DUODENAL ULCER with upper GI endoscopy and proving H. pylori infection by means of rapid urease testing, patients have been randomly distributed in two groups of A (bismuth+amoxicillin+metronidazole) and B (furazolidone+amoxicillin+metronidazole). These regimens were continued for two weeks. One month later all the patients have undertaken another upper GI endoscopy. This time if the rapid urease test was negative an antral biopsy was sent for pathologic evaluation. Patients were considered treated only if no microorganism was seen. Results: Among 151 patients, 70 had completed their treatment course, where 36 of them belonged to group A and the remaining 34 to group B. The mean age was 43.5 and 38.6 years for group A and B, respectively. Conclusion: At the end of the study, 23 patients (63.8%) in group A and 30 patients (88.2%) in group B became free of organism. Serious side effects including confusion and dyspnea were reported in 4 patients (all in group B). Results have revealed that FURAZOLIDONE-containing regimen is much more effective than BISMUTH-containing drugs in eradicating of H. pylori.

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APA: Copy

HOMAYOUNI, MOHAMMAD, ZOJAJI, H., MEHRABIAN, A.A., & AHMADZADEH, A.. (2001). COMPARING THE EFFICACY OF FURAZOLIDONE-CONTAINING AND BISMUTH-CONTAINING DRUGS IN ERADICATION OF HELICOBACTER PYLORI IN PATIENTS WITH DUODENAL ULCER. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 6(1 (21)), 57-62. SID. https://sid.ir/paper/527870/en

Vancouver: Copy

HOMAYOUNI MOHAMMAD, ZOJAJI H., MEHRABIAN A.A., AHMADZADEH A.. COMPARING THE EFFICACY OF FURAZOLIDONE-CONTAINING AND BISMUTH-CONTAINING DRUGS IN ERADICATION OF HELICOBACTER PYLORI IN PATIENTS WITH DUODENAL ULCER. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2001;6(1 (21)):57-62. Available from: https://sid.ir/paper/527870/en

IEEE: Copy

MOHAMMAD HOMAYOUNI, H. ZOJAJI, A.A. MEHRABIAN, and A. AHMADZADEH, “COMPARING THE EFFICACY OF FURAZOLIDONE-CONTAINING AND BISMUTH-CONTAINING DRUGS IN ERADICATION OF HELICOBACTER PYLORI IN PATIENTS WITH DUODENAL ULCER,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 6, no. 1 (21), pp. 57–62, 2001, [Online]. Available: https://sid.ir/paper/527870/en

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