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Information Journal Paper

Title

DIFFERENT DOSAGE OF CEPHRADIN FOR PREVENTION OF ORTHOPEDIC SURGERY-INDUCED INFECTION

Pages

  225-230

Abstract

 Background: POSTOPERATIVE INFECTION especially in case of orthopedic surgery is one of the most severe complications. Controversies about antibiotic prophylaxis had made us conducting the present study over the patients referring to Taleghani hospital since 1997 till 1999 to compare two doses of cephradin for prevention of POSTOPERATIVE INFECTION. Materials and methods: This sequential double-blinded clinical trial was carried out over 200 patients. Predisposing factors such as open wound, active infection, artificial heart valve, advanced underlying disease, using immunosuppressive drugs and malnutrition were all exclusion criteria in this study. Patients were randomly divided in two groups of case and control. Primary antibiotic dosage was administered intravenously 30 minutes prior to the operation; however, postoperative dosages of antibiotic were administered in 6-hour intervals. Control group was received 9 dosages of cephradin postoperatively, whereas the case group was given just 3 dosage of cephradin and the remaining 6 dosages were placebo. Clinical criteria, ESR, and culture were used for infection assessment. Results: 200 patients, including 132 males and 68 females, with mean age of 33.1±19.2 years had been studied. Groups were matched according to the age, sex, level of albumin, period of preoperatively hospitalization, and the duration of surgery. Meanwhile, difference between the types of the surgeries was seen. Infection rate of 5% and 6% was rep0l1ed for the case and control group, respectively (N.S). Meanwhile, no significant statistically difference was seen between the superficial and DEEP INFECTION. Conclusion: Changes in dosage of prophylactic cephradin seems to be ineffective for prevention of POSTOPERATIVE INFECTION, so with respect to the known side effects of cephradin lower dosage of cephradin is recommended.

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    APA: Copy

    MOSHIRI, R.A., BADIEZADEH, K., KARIMI, D., & PIRZAD, SH.. (2001). DIFFERENT DOSAGE OF CEPHRADIN FOR PREVENTION OF ORTHOPEDIC SURGERY-INDUCED INFECTION. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 6(3 (23)), 225-230. SID. https://sid.ir/paper/527871/en

    Vancouver: Copy

    MOSHIRI R.A., BADIEZADEH K., KARIMI D., PIRZAD SH.. DIFFERENT DOSAGE OF CEPHRADIN FOR PREVENTION OF ORTHOPEDIC SURGERY-INDUCED INFECTION. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2001;6(3 (23)):225-230. Available from: https://sid.ir/paper/527871/en

    IEEE: Copy

    R.A. MOSHIRI, K. BADIEZADEH, D. KARIMI, and SH. PIRZAD, “DIFFERENT DOSAGE OF CEPHRADIN FOR PREVENTION OF ORTHOPEDIC SURGERY-INDUCED INFECTION,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 6, no. 3 (23), pp. 225–230, 2001, [Online]. Available: https://sid.ir/paper/527871/en

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