ASSOCIATION OF LIPOPROTEINS, APOLIPOPROTEINS AND PARAOXONASE ENZYME AND PREMATURE CORONARY ARTERY DISEASE

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RAHMANI M.; RAIS ZADEH F.; SOULATI M.; HEDAYATI S.M.; MIROULIAEI M.

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Journal Paper

Paper Information

Journal: KOWSAR MEDICAL JOURNAL Year:2002 | Volume:6 | Issue:part 4 Page(s): 253-260

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Title

ASSOCIATION OF LIPOPROTEINS, APOLIPOPROTEINS AND PARAOXONASE ENZYME AND PREMATURE CORONARY ARTERY DISEASE

Author(s)

Keywords

CORONARY ARTERY DISEASE

LIPOPROTEIN

APOLIPOPROTEIN

PARAOXONASE.

Abstract

The association of serum APOLIPOPROTEIN (apo) A-I and apo B concentrations, and paraoxonase (PON) enzyme activity with angiographically determined coronary artery disease (CAD) was investigated in Iranian nondiabetic patients with premature CAD and normal coronary artery control subjects in a sex and age matched case-control study. The study population consisted of 59 nondiabetics subjects with premature CAD (25 men and 34 women) and 55 CAD- controls (21 men and 34 women) who were referred for their first coronary angiography. Premature CAD was defined as presence of angiographically detected coronary stenosis (> 50% in 1 or more coronary arteries) in men younger than 55 and in women younger than 65 years of age. CAD- was defined as a maximum stenosis of 10% in any coronary artery. All study participants had fasting blood sugar levels of less than 140 mg/dl and had no history of taking oral hypoglycemic agents. Apo concentrations were measured by immunoturbidometric assay and Pon/arylesterase activities by spectrophotometric assay of p-nitrophenol/phenol production following addition of paraoxon /phenylacetate to serum. No significant difference was observed in mean age of CAD and control groups (52.5 ± 6.4 vs 52.5 ± 7.4). In CAD patients, increased concentration of total cholesterol (215 ± 43 vs 193 ± 43, P<0.05) triglycerides (169 ± 125 vs 156 ± 118, P<0.05) LDL-C (138 ± 46 vs 116 ± 39, P<0.05) and apo B (102 ± 24 vs 84 ± 17.5, P+ group and CAD- controls was apo B. It is concluded that in Iranian nondiabetic patients with premature CAD, the concentration of apo B is a better marker than traditional lipid parameters in discriminating between CAD+ and CAD- subjects. Lack of significant difference in poN activity berween CAD+ patients and CAD- controls supports the concept of interethnic variability in poN polymorphism observed in other studies.

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APA: Copy

RAHMANI, M., RAIS ZADEH, F., SOULATI, M., HEDAYATI, S.M., MIROULIAEI, M.,. (2002). ASSOCIATION OF LIPOPROTEINS, APOLIPOPROTEINS AND PARAOXONASE ENZYME AND PREMATURE CORONARY ARTERY DISEASE. KOWSAR MEDICAL JOURNAL, 6(part 4), 253-260. SID. https://sid.ir/paper/528258/en

Vancouver: Copy

RAHMANI M., RAIS ZADEH F., SOULATI M., HEDAYATI S.M., MIROULIAEI M.. ASSOCIATION OF LIPOPROTEINS, APOLIPOPROTEINS AND PARAOXONASE ENZYME AND PREMATURE CORONARY ARTERY DISEASE. KOWSAR MEDICAL JOURNAL[Internet]. 2002;6(part 4):253-260. Available from: https://sid.ir/paper/528258/en

IEEE: Copy

M. RAHMANI, F. RAIS ZADEH, M. SOULATI, S.M. HEDAYATI, M. MIROULIAEI, an, “ASSOCIATION OF LIPOPROTEINS, APOLIPOPROTEINS AND PARAOXONASE ENZYME AND PREMATURE CORONARY ARTERY DISEASE,” KOWSAR MEDICAL JOURNAL, vol. 6, no. part 4, pp. 253–260, 2002, [Online]. Available: https://sid.ir/paper/528258/en

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