CALCULATION OF 99MTC-DTPA TRANSIT TIMES IN NORMAL KIDNEY

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RAJABI H.; SHALCHIAN B.; YAGHOUBI N.; BITARAFAN RAJABI A.; RASTGOU F.; FIROUZABADI SH.

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2003 | Volume:- | Issue:20 Page(s): 41-48

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Title

CALCULATION OF 99MTC-DTPA TRANSIT TIMES IN NORMAL KIDNEY

Author(s)

Keywords

DECONVOLUTION

RENAL TRANSIT TIME PARAMETERS

IRF

Abstract

Introduction: Renal dynamic study is a well-established and popular test in routine practice of nuclear medicine. The test is non-invasive, rapid and unique in evaluation of the kidney function. In despite of its clinical values, the parameters derived from renogram are physiologically meaningless. That is due to the fact that renogram is not the true kidney function. From mathematical points of view, renogram is the convolution of kidney function and kidney input function. The real kidney function, which is usually called Impulse Retention Function, could be derived using disconsolation technique. The main parameters that can be derived from IRF are transit times. Methods and Materials: The data collected from 30 normal healthy individual volunteers were used for calculation of transit times. Due to sensitivity of the disconsolation technique to the error and to minimize the error in the raw data, an investigation was launched to determine the most suitable method of noise reduction, background subtraction and numerical method of disconsolation. Based on our finding, a software package was developed on the system and evaluated using software phantom. Results: Our results shows that among different transit time parameters for different parts of the kidney, mean transit time of the parenchyma is statistically the most valuable parameter. Assuming a Gaussian distribution for the parameter and accepting a 95% confidence interval, the normal rage of mean parenchyma transit time was calculated to be "205±70 Sec". Using the same logic, the abnormal rage of mean parenchyma transit time was calculated to be more than 300 sec. Discussion: During the last decade, skeptical questions have raised about the suitability of renogram for disconsolation and validity of transit time parameters. Our experiences have proved that kidney is approximately a linear and stationary system, therefore suitable for disconsolation. The validity of transit time parameters is extremely depended on the validity of software being used. Commercial software usually dont have sufficient accuracy for calculation of transit times.

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APA: Copy

RAJABI, H., SHALCHIAN, B., YAGHOUBI, N., BITARAFAN RAJABI, A., RASTGOU, F., & FIROUZABADI, SH.. (2003). CALCULATION OF 99MTC-DTPA TRANSIT TIMES IN NORMAL KIDNEY. IRANIAN JOURNAL OF NUCLEAR MEDICINE, -(20), 41-48. SID. https://sid.ir/paper/528273/en

Vancouver: Copy

RAJABI H., SHALCHIAN B., YAGHOUBI N., BITARAFAN RAJABI A., RASTGOU F., FIROUZABADI SH.. CALCULATION OF 99MTC-DTPA TRANSIT TIMES IN NORMAL KIDNEY. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2003;-(20):41-48. Available from: https://sid.ir/paper/528273/en

IEEE: Copy

H. RAJABI, B. SHALCHIAN, N. YAGHOUBI, A. BITARAFAN RAJABI, F. RASTGOU, and SH. FIROUZABADI, “CALCULATION OF 99MTC-DTPA TRANSIT TIMES IN NORMAL KIDNEY,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. -, no. 20, pp. 41–48, 2003, [Online]. Available: https://sid.ir/paper/528273/en

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