SEROPREVALENCE STUDY OF ANTI-CYTOMEGALOVIRUS ANTIBODIES IN INDIVIDUALS INFECTED WITH HIV VIRUS IN QOM REGIONAL BLOOD TRANSFUSION CENTER

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MARDANI A.; HOSSIENI GAVANLOOEI S.

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2006 | Volume:11 | Issue:34 Page(s): 31-34

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Title

SEROPREVALENCE STUDY OF ANTI-CYTOMEGALOVIRUS ANTIBODIES IN INDIVIDUALS INFECTED WITH HIV VIRUS IN QOM REGIONAL BLOOD TRANSFUSION CENTER

Author(s)

MARDANI A. | HOSSIENI GAVANLOOEI S. | Issue Writer Certificate

Keywords

SEROPREVALENCEQ4

CYTOMEGALOVIRUS INFECTIONQ3

HIV VIRUSQ3

QOMQ3

Abstract

Background and Objectives: Cytomegalovirus (CMV) is one the most prevalent opportunist infections agents in patients with HIVIAIDS which caused to making various syndromes such as chorioretinitis, encephalitis, Pneumonia and gastroenteritis in patients with AIDS. This virus is of herpesviruses family and can be seen in all fluids of infected individuals. Infection with cytomegalovirus has a worldwide spreading, as if the rate of infection is variant from 45% in developed countries to 100% in developing countries.The main purpose of this study is determination of SEROPREVALENCE of anti-CMV antibodies (IgG and IgM) in individuals infected with HIV VIRUS, and its last purpose is prevention of CYTOMEGALOVIRUS INFECTION in HIV positive individuals and promotion of level of healthcare.Materials and methods: In this Cross-sectional study 75 serum samples from individuals infected with HIV VIRUS (Including 48 serum samples which is sent to Quality Control laboratory of QOM regional blood transfusion center, 24 serum samples from prisoners of scout plan and 3 serum samples from donors) from tir 1382 until khordad 1383 were examined after confirming existence of anti-HIV by using Western blot method, from the viewpoint of anti-CMV antibodies (IgG and IgM) by ELISA method using diagnostic kit CMV-IgG and CMV-IgM made in Equipar company in Italy. Personal Identifications of 75 individuals infected with HIV VIRUS such as sex, age, marriage status, level of education, record of addiction and record of prison collected from existing files in consultation center of AIDS in QOM Health Center after carrying out related tests, and then were considerated and analyzed statistically. Results: Among 75 serum samples which were examined by IgG-ELISA method, 53 people (70.66%) had special antibody IgG (more than 0.5 u/ml) and all of the serum samples were negative from the viewpoint of existing anti-CMV antibody IgM by using IgM-ELISA method. All of 53 people whose IgG-ELISA test were positive, were male and 41 people (77.35%) were 20-35 years old and 12 people (22.65%) were 36-50 years old. Among 53 people, 27 people (50.49%) were single and 26 people (49.06%) were married. From the viewpoint of level of education, 4 people (7.54%) were illiterate people, 36 people (67.93%) had elementary education and guidance education and 13 people (24.53%) had secondary education. 33 people (62.26%) among 53 people, who had anti-CMV special antibody, had record of injectional addiction, and 27 people (50.49%) had record of prison.Conclusions: The results indicate that 70.66% (53 people) individuals infected with HIV VIRUS, who were examined in this research, have anti-CMV antibody IgG. Since infection with this virus can dangerous and deathful diseases in patients with AIDS, so, chymoprophylaxis with Ganciclovir should be done in individuals who infected with HIV VIRUS who have special antibody against cytomegalovirus and their CD4+ cells count is less than 50.

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APA: Copy

MARDANI, A., & HOSSIENI GAVANLOOEI, S.. (2006). SEROPREVALENCE STUDY OF ANTI-CYTOMEGALOVIRUS ANTIBODIES IN INDIVIDUALS INFECTED WITH HIV VIRUS IN QOM REGIONAL BLOOD TRANSFUSION CENTER. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 11(34), 31-34. SID. https://sid.ir/paper/52876/en

Vancouver: Copy

MARDANI A., HOSSIENI GAVANLOOEI S.. SEROPREVALENCE STUDY OF ANTI-CYTOMEGALOVIRUS ANTIBODIES IN INDIVIDUALS INFECTED WITH HIV VIRUS IN QOM REGIONAL BLOOD TRANSFUSION CENTER. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2006;11(34):31-34. Available from: https://sid.ir/paper/52876/en

IEEE: Copy

A. MARDANI, and S. HOSSIENI GAVANLOOEI, “SEROPREVALENCE STUDY OF ANTI-CYTOMEGALOVIRUS ANTIBODIES IN INDIVIDUALS INFECTED WITH HIV VIRUS IN QOM REGIONAL BLOOD TRANSFUSION CENTER,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 11, no. 34, pp. 31–34, 2006, [Online]. Available: https://sid.ir/paper/52876/en

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