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Title

@ SEROEPIDEMIOLOGY OF ENTEROVIRUS 70 AND COXSACKIEVIRUS A24 IN IRAN

Pages

  63-67

Abstract

 Background: Enterovirus 70 (EV70) and Coxsackievirus A24 variant (CA24v) are the etiologic agents of acute hemorrhagic conjunctivitis (AHC). The two viruses were isolated in early 1970s in Japan and Singapore, respectively. EV70 was responsible for two pandemics and several outbreaks worldwide affecting millions of people. CA24v has been responsible for several outbreaks of AHC especially in the Southeast Asian countries. Despite reports from Mediterranean region and Middle East there are no records of EV70 or CA24v infections in Iran. We conducted a serologic study to obtain such information.Material and Methods: Blood samples were collected from 66 donors in Tehran, Iran. Serum was separated under sterile conditions, stored below -20°C until shipped on dry ice to the Enterovirus Research Centre, Mumbai, India. LLC-MK2 and HeLa cell lines were used for testing samples for antibodies against EV70 and CA24v, respectively. Virus neutralization test was carried out in microtitre plates using serial two-fold dilutions of serum and 100TCID50 of the viruses. The highest serum dilution that neutralized the virus infectivity completely was taken as the titer of antibody in the serum.Results: 68% (44/66) sera showed presence of neutralizing antibodies against EV70. Individuals in all age groups showed presence of EV70 antibodies the youngest donor was 4 years old. There was no difference in proportion of anti-EV70 antibody positive samples among men and women. Interestingly, antibodies against CA24v were absent in all the 65 serum samples tested.Conclusions: Iranian population has been exposed to EV70 infections during recent years but not to CA24v. A systematic study of disease burden due to viral AHC in Iran is warranted.

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    APA: Copy

    ESLAMI, M., DESHPANDE, J.M., HOSSEINI TEHRANI, M., & SEYEDIAN, M.A.. (2006). @ SEROEPIDEMIOLOGY OF ENTEROVIRUS 70 AND COXSACKIEVIRUS A24 IN IRAN. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 11(32), 63-67. SID. https://sid.ir/paper/52886/en

    Vancouver: Copy

    ESLAMI M., DESHPANDE J.M., HOSSEINI TEHRANI M., SEYEDIAN M.A.. @ SEROEPIDEMIOLOGY OF ENTEROVIRUS 70 AND COXSACKIEVIRUS A24 IN IRAN. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2006;11(32):63-67. Available from: https://sid.ir/paper/52886/en

    IEEE: Copy

    M. ESLAMI, J.M. DESHPANDE, M. HOSSEINI TEHRANI, and M.A. SEYEDIAN, “@ SEROEPIDEMIOLOGY OF ENTEROVIRUS 70 AND COXSACKIEVIRUS A24 IN IRAN,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 11, no. 32, pp. 63–67, 2006, [Online]. Available: https://sid.ir/paper/52886/en

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