A SURVEY OF LIPODYSTROPHY COMPLICATION IN HIV INFECTED ON HAART. 0 KERMANSHAH, 2004

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VAZIRI S.; JANBAKHSH A.R.; AFSHARIAN MANDANA; RAFIODIN P.; LAQAEI Z.; NAJAFI F.; ALIKHANI A.

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2006 | Volume:11 | Issue:32 Page(s): 1-6

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A SURVEY OF LIPODYSTROPHY COMPLICATION IN HIV INFECTED ON HAART. 0 KERMANSHAH, 2004

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Abstract

Background: Lipodystrophy syndrome is a rather widespread problem between adult HIV infected cases on HAART. Peripheral fat reduction and central fat accumulation, along with metabolic abnormalities such as an increase in LDL serum level and triglyceride, and a decrease in HDL serum level are some of the manifestations of this syndrome. Yet, there is still no valid and accurate diagnostic way to diagnose it. This paper tries to measure the frequency of this complication through clinical and laboratory criteria.Materials and methods: This is a descriptive, cross-sectional study, which examines 18 HIV positive cases on HAART to determine lipodystrophy complication and its severity. To diagnose the abnormalities we used two different approaches: Clinical examination and scoring through laboratory parameters such as (Anion, CD4, HDL, LDL, Triglyceride, Lactate, and gap), age, gender, and HIV infection duration and waist/hip ratio. In both approaches the patients were given some scores. If in self-evaluation or clinical examination the case was given moderate to severe score he was considered with lipodystrophy complication.Results: %27.8 (5 cases) of the cases had lipodystrophy syndrome (at least in one approach). The ways of infection transmission are unsafe sex (%60), injecting drugs (%20), and surgery (%20). The average of CD4 count in cases with lipodystrophy was 616.4mm3; in cases without lipodystrophy the CD4 count level was 610.5mm3. The mean of HIV infection duration in cases with lipodystrophy was 57.8 months and the mean duration of HAART was 35.6 months. In %15 of cases with lipodystrophy, blood cholesterol and LDL level were higher than normal, and in %20 of cases blood HDL level was lower than normal range. Blood triglyceride level and FBS had a normal range in all the cases.Conclusion: The frequency of lipodystrophy in the cases was %27.8 which seems to be higher than a multi-central study which predicted the lipodystrophy to be %20. There was no significant difference between HIV infection duration mean and cases both with and without lipodystrophy though. There was also no significant difference between blood triglyceride level, total cholesterol, HDL and LDL in both groups with and without lipodystrophy syndrome.

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APA: Copy

VAZIRI, S., JANBAKHSH, A.R., AFSHARIAN, MANDANA, RAFIODIN, P., LAQAEI, Z., NAJAFI, F., & ALIKHANI, A.. (2006). A SURVEY OF LIPODYSTROPHY COMPLICATION IN HIV INFECTED ON HAART. 0 KERMANSHAH, 2004. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 11(32), 1-6. SID. https://sid.ir/paper/52891/en

Vancouver: Copy

VAZIRI S., JANBAKHSH A.R., AFSHARIAN MANDANA, RAFIODIN P., LAQAEI Z., NAJAFI F., ALIKHANI A.. A SURVEY OF LIPODYSTROPHY COMPLICATION IN HIV INFECTED ON HAART. 0 KERMANSHAH, 2004. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2006;11(32):1-6. Available from: https://sid.ir/paper/52891/en

IEEE: Copy

S. VAZIRI, A.R. JANBAKHSH, MANDANA AFSHARIAN, P. RAFIODIN, Z. LAQAEI, F. NAJAFI, and A. ALIKHANI, “A SURVEY OF LIPODYSTROPHY COMPLICATION IN HIV INFECTED ON HAART. 0 KERMANSHAH, 2004,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 11, no. 32, pp. 1–6, 2006, [Online]. Available: https://sid.ir/paper/52891/en

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