GENETIC VARIABILITY OF THE S GENE OF HEPATITIS B VIRUS AMONG HIGH RISK PATIENTS WITH OCCULT HBV INFECTION

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RAMEZANI A.; HAMKAR R.; SOUFIAN S.; BANIFAZL M.; IZADI N.; GHAVAMI N.; SOFIAN M.; NAZEM H.; NADRI M.; AHMADI F.; RAZEGHI E.; ESLAMIFAR A.; AGHAKHANI A.

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2010 | Volume:14 | Issue:47 Page(s): 13-18

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Title

GENETIC VARIABILITY OF THE S GENE OF HEPATITIS B VIRUS AMONG HIGH RISK PATIENTS WITH OCCULT HBV INFECTION

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Keywords

OCCULT HEPATITIS B VIRUS (HBV) INFECTIONQ3

S MUTATIONQ3

Abstract

Background and objective: Occult hepatitis B virus (HBV) infection is characterized by presence of HBV infection with undetectable hepatitis B surface antigen (HBsAg). Surface gene mutants have been reported in a variety of patient groups. Due to limited data regarding these mutations in patients with occult HBV infections; we aimed to determine the surface gene mutations of HBV among high risk patients with occult HBV infection.Materials and methods: 395 patients including 289 patients on chronic hemodialysis and 106 HIV infected subjects were enrolled. HBsAg, anti-HBs, anti-HBc and anti-HCV were tested in all subjects. The presence of HBV-DNA was determined in plasma samples of patients with isolated anti-HBc by real-time PCR. In HBV-DNA positive patients, surface gene region was amplified by nested PCR and surface gene mutations were analyzed after direct sequencing.Results: Insertion of a T residue at position 60 and a G residue at position 89 were seen in two isolates which made their HBs proteins nonfunctional and premature stop codons were observed in 2 other isolates via replacing of T by A at position 44 and G by T at position 28 respectively.Amino acid substitution at amino acid position 207 (S207N) was found in the other isolates.Conclusion: Our study suggested that the "a" region mutations did not playa major role in HBsAg detection and other mutations may be responsible for the existence of occult HBV infection and failure to detect HBsAg by routine laboratory tests.

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APA: Copy

RAMEZANI, A., HAMKAR, R., SOUFIAN, S., BANIFAZL, M., IZADI, N., GHAVAMI, N., SOFIAN, M., NAZEM, H., NADRI, M., AHMADI, F., RAZEGHI, E., ESLAMIFAR, A., & AGHAKHANI, A.. (2010). GENETIC VARIABILITY OF THE S GENE OF HEPATITIS B VIRUS AMONG HIGH RISK PATIENTS WITH OCCULT HBV INFECTION. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 14(47), 13-18. SID. https://sid.ir/paper/52895/en

Vancouver: Copy

RAMEZANI A., HAMKAR R., SOUFIAN S., BANIFAZL M., IZADI N., GHAVAMI N., SOFIAN M., NAZEM H., NADRI M., AHMADI F., RAZEGHI E., ESLAMIFAR A., AGHAKHANI A.. GENETIC VARIABILITY OF THE S GENE OF HEPATITIS B VIRUS AMONG HIGH RISK PATIENTS WITH OCCULT HBV INFECTION. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2010;14(47):13-18. Available from: https://sid.ir/paper/52895/en

IEEE: Copy

A. RAMEZANI, R. HAMKAR, S. SOUFIAN, M. BANIFAZL, N. IZADI, N. GHAVAMI, M. SOFIAN, H. NAZEM, M. NADRI, F. AHMADI, E. RAZEGHI, A. ESLAMIFAR, and A. AGHAKHANI, “GENETIC VARIABILITY OF THE S GENE OF HEPATITIS B VIRUS AMONG HIGH RISK PATIENTS WITH OCCULT HBV INFECTION,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 14, no. 47, pp. 13–18, 2010, [Online]. Available: https://sid.ir/paper/52895/en

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