PERSISTENCE OF ANTI-HBS ANTIBODY IN HBV VACCINATED CHILDREN IN A LOW ENDEMIC AREA FOR HBV

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IZADI N.; AGHAKHANI A.; BANIFAZL M.; SOFIAN M.; MAHDAVIANI F.S.; ESLAMIFAR A.; KHADEM SADEGH A.; RAMEZANI A.

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2010 | Volume:14 | Issue:47 Page(s): 39-42

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Title

PERSISTENCE OF ANTI-HBS ANTIBODY IN HBV VACCINATED CHILDREN IN A LOW ENDEMIC AREA FOR HBV

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Keywords

HBVQ3

ANTI-HBSQ2

LOW ENDEMIC AREAQ2

Abstract

Background and objective: hepatitis B virus (RBV) infection is one of the most widespread infections in the world A potential problem of hepatitis B immunization is that hepatitis B surface antibody (anti-HBs) titers decline with age. The present study was designed to investigate the persistence of anti-RBs levels in vaccinated children in a LOW ENDEMIC AREA.Materials and methods: Plasma samples of 938 children between ages of 8 months and 15 years were tested for the presence of anti-RBs.Results: The overall seroprotection rate was 59.6% in vaccinated children. Protective antibody levels can be detected in 65% of one year vaccinees, 30% in 5 years after vaccination, 29% and 24% in 10 and 15 years after vaccination. The mean anti-RBs declined with post-vaccination time (65.66±38.41 mIU/ml in 1 year vaccinees, 59.88±44.37 in 5, 40.37±40.77 in 10 and 37.31±42.91 in 15 years post vaccination). Seroprotection rates decreased significantly with increasing age, due to waning anti-RBs titer over time.Conclusion: Children vaccinated against hepatitis B during infancy may show low levels of antibody during adolescence.Because the issue of booster dosing is still debatable, our data suggest that a booster dose of vaccine may be required in areas where endemicity is low.

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APA: Copy

IZADI, N., AGHAKHANI, A., BANIFAZL, M., SOFIAN, M., MAHDAVIANI, F.S., ESLAMIFAR, A., KHADEM SADEGH, A., & RAMEZANI, A.. (2010). PERSISTENCE OF ANTI-HBS ANTIBODY IN HBV VACCINATED CHILDREN IN A LOW ENDEMIC AREA FOR HBV. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 14(47), 39-42. SID. https://sid.ir/paper/52903/en

Vancouver: Copy

IZADI N., AGHAKHANI A., BANIFAZL M., SOFIAN M., MAHDAVIANI F.S., ESLAMIFAR A., KHADEM SADEGH A., RAMEZANI A.. PERSISTENCE OF ANTI-HBS ANTIBODY IN HBV VACCINATED CHILDREN IN A LOW ENDEMIC AREA FOR HBV. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2010;14(47):39-42. Available from: https://sid.ir/paper/52903/en

IEEE: Copy

N. IZADI, A. AGHAKHANI, M. BANIFAZL, M. SOFIAN, F.S. MAHDAVIANI, A. ESLAMIFAR, A. KHADEM SADEGH, and A. RAMEZANI, “PERSISTENCE OF ANTI-HBS ANTIBODY IN HBV VACCINATED CHILDREN IN A LOW ENDEMIC AREA FOR HBV,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 14, no. 47, pp. 39–42, 2010, [Online]. Available: https://sid.ir/paper/52903/en

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